(S)-cyclopentyl(hydroxymethyl)phenyl[2-(piperidin-1-yl)ethyl]germane

Base Information

Chemical Name:(S)-cyclopentyl(hydroxymethyl)phenyl[2-(piperidin-1-yl)ethyl]germane
CAS No.:405072-31-3
Molecular Formula:C₁₉H₃₁GeNO
Molecular Weight:362.051
Hs Code.:

Synonyms:

Suppliers and Price of (S)-cyclopentyl(hydroxymethyl)phenyl[2-(piperidin-1-yl)ethyl]germane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-cyclopentyl(hydroxymethyl)phenyl[2-(piperidin-1-yl)ethyl]germane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-cyclopentyl(hydroxymethyl)phenyl[2-(piperidin-1-yl)ethyl]germane

There total 1 articles about (S)-cyclopentyl(hydroxymethyl)phenyl[2-(piperidin-1-yl)ethyl]germane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 4.0%

: 405072-25-5
rac-cyclopentyl(hydroxymethyl)phenyl[2-(piperidin-1-yl)ethyl]germane

: 405072-31-3
(S)-cyclopentyl(hydroxymethyl)phenyl[2-(piperidin-1-yl)ethyl]germane

Guidance literature:: With (R)-1,1'-binaphtyl-2,2'-diyl hydrogen phosphate; In ethanol; (N2); soln. of (S)-phosphate in boiling EtOH added to soln. of Ge compd.in EtOH; mixt. refluxed for 30 min; H2O added until ppt.; EtOH added to boiling soln. until ppt. disappeared; filtered; cooled to room temp. wi thin 10 h; mixt. was kept for 48 h; filtered; mother liquors evapd. (vac.) and added to mixt. of aq. NaOH and Et2O; stirred at room temp. for 30 min; org. phase septd.; aq. phase extd. (Et2O); dried (Na2SO4); solvent removed (vac.); dried (vac.); soln.of (R)-phosphate added; elem. anal.;
DOI:10.1016/S0022-328X(01)01179-2

Reference yield: 98.0%

: 405072-31-3
(S)-cyclopentyl(hydroxymethyl)phenyl[2-(piperidin-1-yl)ethyl]germane

: 74-88-4
methyl iodide

: 405072-40-4
(S)-1-(2-[cyclopentyl(hydroxymethyl)phenylgermyl]ethyl)-1-methylpiperidinium iodide

Guidance literature:: In acetone; (N2); CH3I was added to soln. of Ge compd. in acetone; mixt. was stirredat room temp. for 21 h; solvent and MeI removed (vac.); residue dried (vac.); recrystd. (acetone/Et2O); elem. anal.;
DOI:10.1016/S0022-328X(01)01179-2

Reference yield: 97.0%

: 7647-01-0,15364-23-5
hydrogenchloride

: 405072-31-3
(S)-cyclopentyl(hydroxymethyl)phenyl[2-(piperidin-1-yl)ethyl]germane

: 405158-11-4
(S)-1-(2-[cyclopentyl(hydroxymethyl)phenylgermyl]ethyl)piperidinium chloride

Guidance literature:: In diethyl ether; (N2); satd. soln. of HCl in Et2O was added to stirred soln. of Ge compd.in Et2O; mixt. was stirred at room temp. for 15 h; filtered; washed (Et2O); dried (vac.); elem. anal.;
DOI:10.1016/S0022-328X(01)01179-2