AZD1152

Base Information

Chemical Name:AZD1152
CAS No.:957881-03-7
Molecular Formula:C₂₆H₃₁FN₇O₆P
Molecular Weight:587.548
Hs Code.:
Mol file:957881-03-7.mol

Synonyms:3-[[7-[3-[Ethyl[2-(phosphonooxy)ethyl]amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-1H-pyrazole-5-acetamide;

Suppliers and Price of AZD1152

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Biorbyt Ltd
AZD1152 (barasertib) >98%
250 mg
$ 1654.10

Biorbyt Ltd
AZD1152 (barasertib) >98%
100 mg
$ 912.90

Biorbyt Ltd
AZD1152 (barasertib) >98%
1000 mg
$ 3282.70

American Custom Chemicals Corporation
AZD-1152 95.00%
50MG
$ 2194.50

American Custom Chemicals Corporation
AZD-1152 95.00%
5MG
$ 298.10

Total 26 raw suppliers

Chemical Property of AZD1152

Chemical Property:

PSA：191.35000
Density:1.463
LogP:3.68830

Purity/Quality:

97% ^*data from raw suppliers

AZD1152 (barasertib) >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses As an Aurora kinase inhibitor, AZD1152 can be used to treat patients with advanced solid tumors.

Technology Process of AZD1152

There total 12 articles about AZD1152 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: mono(tert-butyl) 2-[[3-([4-[(5-[2-[(3-fluorophenyl)amino]-2-oxoethyl]-1H-pyrazol-3-yl)amino]-quinazolin-7-yl]oxy)propyl](ethyl)amino]ethyl phosphate

: 957881-03-7,722543-31-9
2-{ethyl[3-({4-[(5-{2-[(3-fluorophenyl)amino]-2-oxoethyl}-1H-pyrazol-3-yl)amino]quinazolin-7-yl}oxy)proplyl]amino}ethyl dihydrogen phosphate

Guidance literature:: mono(tert-butyl) 2-[[3-([4-[(5-[2-[(3-fluorophenyl)amino]-2-oxoethyl]-1H-pyrazol-3-yl)amino]-quinazolin-7-yl]oxy)propyl](ethyl)amino]ethyl phosphate; With hydrogenchloride; water; In tetrahydrofuran; at 55 - 65 ℃; for 1h;

With sodium hydroxide; water; In tetrahydrofuran; at 55 - 65 ℃; for 1h; pH=5.0 - 5.5;

Reference yield: 73.0%

: Barasertib dihydrochloride

: 957881-03-7,722543-31-9
2-{ethyl[3-({4-[(5-{2-[(3-fluorophenyl)amino]-2-oxoethyl}-1H-pyrazol-3-yl)amino]quinazolin-7-yl}oxy)proplyl]amino}ethyl dihydrogen phosphate

Guidance literature:: With cyclohexane-1,2-epoxide; In methanol; at 20 ℃;
DOI:10.1021/jm061335f

Reference yield:

: 722544-46-9
2-(5-{[7-(3-chloropropoxy)quinazolin-4-yl]amino}-2H-pyrazol-3-yl)-N-(3-fluorophenyl)acetamide

: 957881-03-7,722543-31-9
2-{ethyl[3-({4-[(5-{2-[(3-fluorophenyl)amino]-2-oxoethyl}-1H-pyrazol-3-yl)amino]quinazolin-7-yl}oxy)proplyl]amino}ethyl dihydrogen phosphate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 59 percent / potassium iodide / N,N-dimethyl-acetamide / 50 °C

2.1: tetrazole / dimethylformamide / 20 °C

2.2: 63 percent / aq. hydrogen peroxide / dimethylformamide / 2 h / 20 °C

3.1: 99 percent / HCl / dioxane / 20 - 45 °C

4.1: 73 percent / cyclohexene oxide / methanol / 20 °C

With 1H-tetrazole; hydrogenchloride; cyclohexane-1,2-epoxide; potassium iodide; In 1,4-dioxane; methanol; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1021/jm061335f