Chemical Property of Azd-1152hqpa
Chemical Property:
- Vapor Pressure:9.07E-27mmHg at 25°C
- Refractive Index:1.677
- Boiling Point:796.7 °C at 760 mmHg
- PKA:13.07±0.10(Predicted)
- Flash Point:435.6 °C
- PSA：128.29000
- Density:1.359 g/cm3
- LogP:3.64590
- Storage Temp.:2-8°C
- Solubility.:DMSO: >15mg/mL
- XLogP3:3
- Hydrogen Bond Donor Count:4
- Hydrogen Bond Acceptor Count:9
- Rotatable Bond Count:13
- Exact Mass:507.23941601
- Heavy Atom Count:37
- Complexity:693
- Purity/Quality:
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99%, *data from raw suppliers
AZD1152-HQPA *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CCN(CCCOC1=CC2=C(C=C1)C(=NC=N2)NC3=NNC(=C3)CC(=O)NC4=CC(=CC=C4)F)CCO
- Recent ClinicalTrials:Study of AZD2811 + Durvalumab in ES-SCLC
- Recent EU Clinical Trials:A Phase II Multicenter, Open-Label, Single Arm Study to
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Description
AZD1152-HQPA (722544-51-6) is a potent and highly selective inhibitor of Aurora B.1?Aurora B Ki?= 0.36 nM; Aurora A Ki?= 1,369 nM.2?It inhibits the growth of tumors in multiple cancer models.3-6?Excessive ROS generation7?and upregulated tumor suppressor miRNAs8?have been proposed as a novel mechanisms of cytotoxicity of AZD1152-HQPA.
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Uses
AZD1152-HQPA is a a highly selective inhibitor of aurora-B kinase. AZD1152-HQPA has been shown to inhibit osteosarcoma cell line U2-OS cells proliferation. AZD1152-HQPA was also shown to be an effective apoptosis-inducing agent in acute myeloid leukemia cell lines and primary acute myeloid leukemia cultures. AZD1152-HQPA has been used:for the dose dependent inhibition of aurora kinase B (AURKB)as a component to identify that, replication timing regulatory factor 1 (RIF1) and protein phosphatase 1 (PP1) are critical for the regulation of abscission timing in human cellsas a component to study the relevance of AURKB as a cancer therapeutic target
