4-ClBz-L-Ala-L-PheOMe

Base Information

• Chemical Name: 4-ClBz-L-Ala-L-PheOMe
• CAS No.: 93709-84-3
• Molecular Formula: C₂₀H₂₁ClN₂O₄
• Molecular Weight: 388.851
• Mol file: 93709-84-3.mol

Synonyms:

Chemical Property of 4-ClBz-L-Ala-L-PheOMe

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-ClBz-L-Ala-L-PheOMe

There total 4 articles about 4-ClBz-L-Ala-L-PheOMe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(p-chlorobenzoyl)-L-alanine (63013-10-5) + methyl (2S)-2-amino-3-phenylpropanoate hydrochloride (7524-50-7) → 4-ClBz-L-Ala-L-PheOMe (93709-84-3)

Guidance literature:

With 1-hydroxy-pyrrolidine-2,5-dione; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1002/cber.19681010323

Reference yield:

N-(p-chlorobenzoyl)-L-alanine (63013-10-5) + methyl (2S)-2-amino-3-phenylpropanoate hydrochloride (7524-50-7) → 4-ClBz-L-Ala-L-PheOMe (93709-84-3) + 4-ClBz-D-Ala-L-PheOMe (93710-10-2)

Guidance literature:

With triethylamine; dicyclohexyl-carbodiimide; In chloroform; at 0 - 20 ℃; Yield given. Yields of byproduct given. Title compound not separated from byproducts; racemisation;

Reference yield:

4-chloro-benzoyl chloride (122-01-0) → 4-ClBz-L-Ala-L-PheOMe (93709-84-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 2M aq. NaOH / 0 - 20 °C / Schotten-Baumann method

2: N,N'-dicyclohexylcarbodiimide, N-hydroxybenzotriazole, triethylamine / CHCl₃ / 12 h / -20 °C / without HOBt at RT, overnight: racemisation

With sodium hydroxide; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In chloroform;

upstream raw materials:

N-(p-chlorobenzoyl)-L-alanine

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

4-chloro-benzoyl chloride

Downstream raw materials:

N-(p-Chlor-benzoyl)-Ala-Phe