cis-3-Hydroxycyclobutanecarboxylic acid

Base Information

• Chemical Name: cis-3-Hydroxycyclobutanecarboxylic acid
• CAS No.: 552849-33-9
• Molecular Formula: C₅H₈O₃
• Molecular Weight: 116.117
• Hs Code.: 2918199890
• Mol file: 552849-33-9.mol

Synonyms:cyclobutanecarboxylic acid, 3-hydroxy-, cis-;

Chemical Property of cis-3-Hydroxycyclobutanecarboxylic acid

Chemical Property:

• Refractive Index: 1.565
• Boiling Point: 290.129 °C at 760 mmHg
• PKA: 4.54±0.40(Predicted)
• Flash Point: 143.5 °C
• PSA: 57.53000
• Density: 1.448g/cm³
• LogP: -0.15810
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Cis-3-Hydroxycyclobutanecarboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of cis-3-Hydroxycyclobutanecarboxylic acid

There total 4 articles about cis-3-Hydroxycyclobutanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

methylester of 3-hydroxycyclobutane-1-carboxylic acid (4934-99-0) → cis-3-hydroxycyclobutylcarboxylic acid (194788-10-8,552849-33-9,1268521-85-2)

Guidance literature:

With lithium hydroxide monohydrate; In tetrahydrofuran; water; at 20 ℃;

Reference yield: 81.0%

trans-p-nitrobenzoic acid (3-methoxycarbonylcyclobutyl) ester → (1r,3r)‐3‐hydroxycyclobutane‐1‐carboxylic acid (552849-33-9,1268521-85-2)

Guidance literature:

With lithium hydroxide monohydrate; In tetrahydrofuran; water; at 20 ℃; Large scale;

Reference yield:

3-hydroxycyclobutylcarboxylic acid benzyl ester (480449-99-8,128041-58-7) → cis-3-hydroxycyclobutylcarboxylic acid (194788-10-8,552849-33-9,1268521-85-2)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃; for 2h;

upstream raw materials:

3-hydroxycyclobutylcarboxylic acid benzyl ester

methylester of 3-hydroxycyclobutane-1-carboxylic acid

methyl 3-oxocyclobutanecarboxylate

Downstream raw materials:

3-hydroxy-N-methylcyclobutanecarboxamide

Refernces

• 1、 -. "Method for synthesizing trans-3-hydroxy cyclobutyl formic acid". Paragraph 0057; 0058. . Retrieved 2018/07/06.
• 2、 -. "Diamine derivatives". . . Retrieved 2008/06/13.