N-[(1S,2S,4R)-4-cyclopropylcarbamoyl-1-(3,5-difluorophenoxymethyl)-2-hydroxy-4-methoxy-butyl]-5-(methanesulfonyl(methyl)amino)-N'-((R)-1-phenyl-ethyl)-isophthalamide

Base Information

Chemical Name:N-[(1S,2S,4R)-4-cyclopropylcarbamoyl-1-(3,5-difluorophenoxymethyl)-2-hydroxy-4-methoxy-butyl]-5-(methanesulfonyl(methyl)amino)-N'-((R)-1-phenyl-ethyl)-isophthalamide
CAS No.:1067651-22-2
Molecular Formula:C₃₄H₄₀F₂N₄O₈S
Molecular Weight:702.776
Hs Code.:

N-[(1S,2S,4R)-4-cyclopropylcarbamoyl-1-(3,5-difluorophenoxymethyl)-2-hydroxy-4-methoxy-butyl]-5-(methanesulfonyl(methyl)amino)-N'-((R)-1-phenyl-ethyl)-isophthalamide

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Chemical Property of N-[(1S,2S,4R)-4-cyclopropylcarbamoyl-1-(3,5-difluorophenoxymethyl)-2-hydroxy-4-methoxy-butyl]-5-(methanesulfonyl(methyl)amino)-N'-((R)-1-phenyl-ethyl)-isophthalamide

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Technology Process of N-[(1S,2S,4R)-4-cyclopropylcarbamoyl-1-(3,5-difluorophenoxymethyl)-2-hydroxy-4-methoxy-butyl]-5-(methanesulfonyl(methyl)amino)-N'-((R)-1-phenyl-ethyl)-isophthalamide

There total 2 articles about N-[(1S,2S,4R)-4-cyclopropylcarbamoyl-1-(3,5-difluorophenoxymethyl)-2-hydroxy-4-methoxy-butyl]-5-(methanesulfonyl(methyl)amino)-N'-((R)-1-phenyl-ethyl)-isophthalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1067651-22-2
N-[(1S,2S,4R)-4-cyclopropylcarbamoyl-1-(3,5-difluorophenoxymethyl)-2-hydroxy-4-methoxy-butyl]-5-(methanesulfonyl(methyl)amino)-N'-((R)-1-phenyl-ethyl)-isophthalamide

Guidance literature:

Reference yield:

: 1067652-49-6
C₁₆H₂₂F₂N₂O₄

: 695215-92-0
3-[methyl(methylsulfonyl)amino]-5-((1R)-1-phenylethylaminocarbonyl)benzoate acid

: 1067651-22-2
N-[(1S,2S,4R)-4-cyclopropylcarbamoyl-1-(3,5-difluorophenoxymethyl)-2-hydroxy-4-methoxy-butyl]-5-(methanesulfonyl(methyl)amino)-N'-((R)-1-phenyl-ethyl)-isophthalamide

Guidance literature:: 3-[methyl(methylsulfonyl)amino]-5-((1R)-1-phenylethylaminocarbonyl)benzoate acid; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.5h;

C₁₆H₂₂F₂N₂O₄; With N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1021/jm901168f