N-[4-((S)-2-Carbamoyl-2-{[(S)-1-(3,5-dichloro-benzenesulfonyl)-pyrrolidine-2-carbonyl]-amino}-ethyl)-phenyl]-3,5-dichloro-isonicotinamide

Base Information

• Chemical Name: N-[4-((S)-2-Carbamoyl-2-{[(S)-1-(3,5-dichloro-benzenesulfonyl)-pyrrolidine-2-carbonyl]-amino}-ethyl)-phenyl]-3,5-dichloro-isonicotinamide
• CAS No.: 872493-11-3
• Molecular Formula: C₂₆H₂₃Cl₄N₅O₅S
• Molecular Weight: 659.377
• Mol file: 872493-11-3.mol

Synonyms:

Chemical Property of N-[4-((S)-2-Carbamoyl-2-{[(S)-1-(3,5-dichloro-benzenesulfonyl)-pyrrolidine-2-carbonyl]-amino}-ethyl)-phenyl]-3,5-dichloro-isonicotinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[4-((S)-2-Carbamoyl-2-{[(S)-1-(3,5-dichloro-benzenesulfonyl)-pyrrolidine-2-carbonyl]-amino}-ethyl)-phenyl]-3,5-dichloro-isonicotinamide

There total 1 articles about N-[4-((S)-2-Carbamoyl-2-{[(S)-1-(3,5-dichloro-benzenesulfonyl)-pyrrolidine-2-carbonyl]-amino}-ethyl)-phenyl]-3,5-dichloro-isonicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-{[(S)-1-(3,5-Dichloro-benzenesulfonyl)-pyrrolidine-2-carbonyl]-amino}-3-{4-[(3,5-dichloro-pyridine-4-carbonyl)-amino]-phenyl}-propionic acid ethyl ester → N-[4-((S)-2-Carbamoyl-2-{[(S)-1-(3,5-dichloro-benzenesulfonyl)-pyrrolidine-2-carbonyl]-amino}-ethyl)-phenyl]-3,5-dichloro-isonicotinamide (872493-11-3)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. LiOH / tetrahydrofuran

2: NH₃ / methanol

With lithium hydroxide; ammonia; In tetrahydrofuran; methanol;

DOI:10.1016/j.bmcl.2005.06.034

Reference yield:

N-[4-((S)-2-Carbamoyl-2-{[(S)-1-(3,5-dichloro-benzenesulfonyl)-pyrrolidine-2-carbonyl]-amino}-ethyl)-phenyl]-3,5-dichloro-isonicotinamide (872493-11-3) → 3,5-Dichloro-N-[4-((S)-2-cyano-2-{[(S)-1-(3,5-dichloro-benzenesulfonyl)-pyrrolidine-2-carbonyl]-amino}-ethyl)-phenyl]-isonicotinamide (866109-56-0)

Guidance literature:

With pyridine; trifluoroacetic anhydride; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2005.06.034

Reference yield:

N-[4-((S)-2-Carbamoyl-2-{[(S)-1-(3,5-dichloro-benzenesulfonyl)-pyrrolidine-2-carbonyl]-amino}-ethyl)-phenyl]-3,5-dichloro-isonicotinamide (872493-11-3) → 3,5-dichloro-N-{4-[2-{[1-(3,5-dichloro-benzenesulfonyl)-pyrrolidine-2-carbonyl]-amino}-2-(N-hydroxycarbamimidoyl)-ethyl]-phenyl}-isonicotinamide

Guidance literature:

Multi-step reaction with 2 steps

1: TFAA; pyridine / tetrahydrofuran

2: NH₂OH / ethanol

With pyridine; hydroxylamine; trifluoroacetic anhydride; In tetrahydrofuran; ethanol;

DOI:10.1016/j.bmcl.2005.06.034

Downstream raw materials:

3,5-Dichloro-N-[4-((S)-2-cyano-2-{[(S)-1-(3,5-dichloro-benzenesulfonyl)-pyrrolidine-2-carbonyl]-amino}-ethyl)-phenyl]-isonicotinamide