3,5-Dichloro-N-[4-((S)-2-cyano-2-{[(S)-1-(3,5-dichloro-benzenesulfonyl)-pyrrolidine-2-carbonyl]-amino}-ethyl)-phenyl]-isonicotinamide

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Chemical Name:3,5-Dichloro-N-[4-((S)-2-cyano-2-{[(S)-1-(3,5-dichloro-benzenesulfonyl)-pyrrolidine-2-carbonyl]-amino}-ethyl)-phenyl]-isonicotinamide
CAS No.:866109-56-0
Molecular Formula:C₂₆H₂₁Cl₄N₅O₄S
Molecular Weight:641.362
Hs Code.:

Synonyms:3,5-Dichloro-N-[4-((S)-2-cyano-2-{[(S)-1-(3,5-dichloro-benzenesulfonyl)-pyrrolidine-2-carbonyl]-amino}-ethyl)-phenyl]-isonicotinamide

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Chemical Property of 3,5-Dichloro-N-[4-((S)-2-cyano-2-{[(S)-1-(3,5-dichloro-benzenesulfonyl)-pyrrolidine-2-carbonyl]-amino}-ethyl)-phenyl]-isonicotinamide

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Technology Process of 3,5-Dichloro-N-[4-((S)-2-cyano-2-{[(S)-1-(3,5-dichloro-benzenesulfonyl)-pyrrolidine-2-carbonyl]-amino}-ethyl)-phenyl]-isonicotinamide

There total 3 articles about 3,5-Dichloro-N-[4-((S)-2-cyano-2-{[(S)-1-(3,5-dichloro-benzenesulfonyl)-pyrrolidine-2-carbonyl]-amino}-ethyl)-phenyl]-isonicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 872493-11-3
N-[4-((S)-2-Carbamoyl-2-{[(S)-1-(3,5-dichloro-benzenesulfonyl)-pyrrolidine-2-carbonyl]-amino}-ethyl)-phenyl]-3,5-dichloro-isonicotinamide

: 866109-56-0
3,5-Dichloro-N-[4-((S)-2-cyano-2-{[(S)-1-(3,5-dichloro-benzenesulfonyl)-pyrrolidine-2-carbonyl]-amino}-ethyl)-phenyl]-isonicotinamide

Guidance literature:: With pyridine; trifluoroacetic anhydride; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2005.06.034

Reference yield:

: (S)-2-{[(S)-1-(3,5-Dichloro-benzenesulfonyl)-pyrrolidine-2-carbonyl]-amino}-3-{4-[(3,5-dichloro-pyridine-4-carbonyl)-amino]-phenyl}-propionic acid ethyl ester

: 866109-56-0
3,5-Dichloro-N-[4-((S)-2-cyano-2-{[(S)-1-(3,5-dichloro-benzenesulfonyl)-pyrrolidine-2-carbonyl]-amino}-ethyl)-phenyl]-isonicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1: aq. LiOH / tetrahydrofuran

2: NH₃ / methanol

3: TFAA; pyridine / tetrahydrofuran

With pyridine; lithium hydroxide; ammonia; trifluoroacetic anhydride; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmcl.2005.06.034

Reference yield:

: 462122-84-5
(S)-2-{[(S)-1-(3,5-Dichloro-benzenesulfonyl)-pyrrolidine-2-carbonyl]-amino}-3-{4-[(3,5-dichloro-pyridine-4-carbonyl)-amino]-phenyl}-propionic acid

: 866109-56-0
3,5-Dichloro-N-[4-((S)-2-cyano-2-{[(S)-1-(3,5-dichloro-benzenesulfonyl)-pyrrolidine-2-carbonyl]-amino}-ethyl)-phenyl]-isonicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1: NH₃ / methanol

2: TFAA; pyridine / tetrahydrofuran

With pyridine; ammonia; trifluoroacetic anhydride; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmcl.2005.06.034