Technology Process of (2S,3R)-methyl 3-<(azidocarbonyl)amino>-2--4-phenylbutanoate
There total 9 articles about (2S,3R)-methyl 3-<(azidocarbonyl)amino>-2--4-phenylbutanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 87 percent / Pb(NO3)2, K3PO4 / acetonitrile / 17 h / Ambient temperature
2: 1) KHMDS / 1) THF, toluene, -20 deg C; 2) THF, -20 deg C, 2 h
3: 48 percent / 5percent Pd/BaSO4, H2 / ethyl acetate / 30 h / 760 Torr / Ambient temperature
4: 1) DPPA, triethylamine; 2) sodium azide, tert-butylalcohol / 1) acetonitrile, RT, 0.5 h, then to 50 deg C for 3 h; 2) RT, then 50 deg C for 12 h and at 80 deg C for 2 h
With
potassium phosphate; Pd-BaSO4; sodium azide; lead(II) nitrate; diphenyl-phosphinic acid; hydrogen; potassium hexamethylsilazane; triethylamine; tert-butyl alcohol;
In
ethyl acetate; acetonitrile;
DOI:10.1021/jo00304a011
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 85 percent / sulfuric acid / diethyl ether / 48 h / Ambient temperature
2: 71 percent / acetonitrile / 2 h / Heating
3: 87 percent / Pb(NO3)2, K3PO4 / acetonitrile / 17 h / Ambient temperature
4: 1) KHMDS / 1) THF, toluene, -20 deg C; 2) THF, -20 deg C, 2 h
5: 48 percent / 5percent Pd/BaSO4, H2 / ethyl acetate / 30 h / 760 Torr / Ambient temperature
6: 1) DPPA, triethylamine; 2) sodium azide, tert-butylalcohol / 1) acetonitrile, RT, 0.5 h, then to 50 deg C for 3 h; 2) RT, then 50 deg C for 12 h and at 80 deg C for 2 h
With
potassium phosphate; Pd-BaSO4; sodium azide; lead(II) nitrate; sulfuric acid; diphenyl-phosphinic acid; hydrogen; potassium hexamethylsilazane; triethylamine; tert-butyl alcohol;
In
diethyl ether; ethyl acetate; acetonitrile;
DOI:10.1021/jo00304a011
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 71 percent / acetonitrile / 2 h / Heating
2: 87 percent / Pb(NO3)2, K3PO4 / acetonitrile / 17 h / Ambient temperature
3: 1) KHMDS / 1) THF, toluene, -20 deg C; 2) THF, -20 deg C, 2 h
4: 48 percent / 5percent Pd/BaSO4, H2 / ethyl acetate / 30 h / 760 Torr / Ambient temperature
5: 1) DPPA, triethylamine; 2) sodium azide, tert-butylalcohol / 1) acetonitrile, RT, 0.5 h, then to 50 deg C for 3 h; 2) RT, then 50 deg C for 12 h and at 80 deg C for 2 h
With
potassium phosphate; Pd-BaSO4; sodium azide; lead(II) nitrate; diphenyl-phosphinic acid; hydrogen; potassium hexamethylsilazane; triethylamine; tert-butyl alcohol;
In
ethyl acetate; acetonitrile;
DOI:10.1021/jo00304a011
