117176-17-7Relevant academic research and scientific papers
Electrophilic Amination of Amino Acids with N-Boc-oxaziridines: Efficient Preparation of N-Orthogonally Diprotected Hydrazino Acids and Piperazic Acid Derivatives
Hannachi, Jean-Christophe,Vidal, Joelle,Mulatier, Jean-Christophe,Collet, Andre
, p. 2367 - 2373 (2007/10/03)
A general two-step preparation of enantiopure Nα,N β-orthogonally diprotected α-hydrazino acids 1 is developed on a multigram scale. The key reaction is the efficient electrophilic amination of N-benzyl amino acids 6 with N-Boc-oxaziridine 7 and accommodates various functional groups encountered in side chains of amino acids. The cyclic 2,3,4,5-tetrahydro-3-pyridazine carboxylic acid (piperazic acid) derivatives 2 and 3 or the cyclic 3,4-dihydro-3-pyrazolecarboxylate 4 are conveniently prepared from glutamic acid or aspartic acid via orthogonally diprotected α-hydrazino acids 1m and 1n.
Stereoselective Synthesis of 2,3-Diamino Acids. 2,3-Diamino-4-phenylbutanoic Acid
Dunn, Peter J.,Haener, Robert,Rapoport, Henry
, p. 5017 - 5025 (2007/10/02)
The synthesis of (2S,3S)- and (2S,3R)-2,3-diamino-4-phenylbutanoic acid (1c and 3) from L-aspartic acid is described.The N-(phenylfluorenyl)-protected aspartic acid diesters 4 and 10 (α-tert-butyl, β-methyl), 18 (β-benzyl, α-tert-butyl), and 28 (β-benzyl,
