5-Methyl-2-thiazolemethanol

Base Information

• Chemical Name: 5-Methyl-2-thiazolemethanol
• CAS No.: 202932-04-5
• Molecular Formula: C5H7NOS
• Molecular Weight: 129.183
• Hs Code.: 2934100090
• European Community (EC) Number: 886-234-1
• DSSTox Substance ID: DTXSID40593461
• Wikidata: Q72491225
• Mol file: 202932-04-5.mol

Synonyms:5-Methyl-2-thiazolemethanol;202932-04-5;(5-Methyl-1,3-thiazol-2-yl)methanol;2-Thiazolemethanol, 5-methyl-;MFCD08060774;2-(Hydroxymethyl)-5-methyl-1,3-thiazole;5-Methylthiazole-2-methanol;SCHEMBL2644581;DTXSID40593461;AMY17419;AKOS012221413;CS-W019147;PS-4436;SY109961;DB-066114;C73831

Chemical Property of 5-Methyl-2-thiazolemethanol

Chemical Property:

• Vapor Pressure: 0.05mmHg at 25°C
• Refractive Index: 1.58
• Boiling Point: 225.026 °C at 760 mmHg
• PKA: 13.14±0.10(Predicted)
• Flash Point: 89.893 °C
• PSA: 61.36000
• Density: 1.264 g/cm³
• LogP: 0.94380
• Storage Temp.: 2-8°C
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 129.02483502
• Heavy Atom Count: 8
• Complexity: 78.8

Purity/Quality:

97% ^*data from raw suppliers

5-Methyl-2-thiazolemethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CN=C(S1)CO
• Uses: 5-Methyl-2-thiazolemethanol is a useful reagent in the preparation of functionalized tetrahydro(ethano)triazolo[3,4-a]phthalazines as selective GABAA receptor agonists.

Technology Process of 5-Methyl-2-thiazolemethanol

There total 2 articles about 5-Methyl-2-thiazolemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

5-methyl-1,3-thiazole-2-carbaldehyde (13838-78-3) → (5-methyl-1,3-thiazol-2-yl)methanol (202932-04-5)

Guidance literature:

With sodium tetrahydroborate; In methanol; for 1h;

DOI:10.1021/jm040883v

Reference yield:

→ (5-methyl-1,3-thiazol-2-yl)methanol (202932-04-5)

Guidance literature:

Reference yield: 65.8%

3-hydroxyphenyl propargyl ether (3692-88-4) + (5-methyl-1,3-thiazol-2-yl)methanol (202932-04-5) → 5-methyl-2-((3-(prop-2-yn-1-yloxy)phenoxy)methyl)thiazole

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; di-isopropyl azodicarboxylate; In tetrahydrofuran; at 20 ℃; for 15h; Inert atmosphere;

upstream raw materials:

5-methyl-1,3-thiazole-2-carbaldehyde

Downstream raw materials:

2-(chloromethyl)-5-methylthiazole