2-(Chloromethyl)-5-methyl-1,3-thiazole hydrochloride

Base Information

• Chemical Name: 2-(Chloromethyl)-5-methyl-1,3-thiazole hydrochloride
• CAS No.: 921145-23-5
• Molecular Formula: C5H7Cl2NS
• Molecular Weight: 184.08678
• Hs Code.: 2934100090
• Mol file: 921145-23-5.mol

Synonyms:2-(Chloromethyl)-5-methyl-1,3-thiazole hydrochloride;2-(chloromethyl)-5-methyl-1,3-thiazole

Chemical Property of 2-(Chloromethyl)-5-methyl-1,3-thiazole hydrochloride

Chemical Property:

• Boiling Point: 199.9±23.0 °C(Predicted)
• PKA: 2.48±0.10(Predicted)
• PSA: 41.13000
• Density: 1.271±0.06 g/cm3(Predicted)
• LogP: 2.99230

Purity/Quality:

98%min ^*data from raw suppliers

2-(Chloromethyl)-5-methyl-1,3-thiazolehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(Chloromethyl)-5-methyl-1,3-thiazole hydrochloride

There total 2 articles about 2-(Chloromethyl)-5-methyl-1,3-thiazole hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(5-methyl-1,3-thiazol-2-yl)methanol (202932-04-5) → 2-(chloromethyl)-5-methylthiazole (921145-23-5)

Guidance literature:

With thionyl chloride; In dichloromethane; at 0 - 35 ℃; for 1h;

Reference yield:

5-methyl-1,3-thiazole-2-carbaldehyde (13838-78-3) → 2-(chloromethyl)-5-methylthiazole (921145-23-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol / 1 h / 0 - 35 °C

2: thionyl chloride / dichloromethane / 1 h / 0 - 35 °C

With sodium tetrahydroborate; thionyl chloride; In methanol; dichloromethane;

Reference yield: 49.0%

2-(chloromethyl)-5-methylthiazole (921145-23-5) + diphenylmethylisothiouronium bromide (90280-15-2) → 2-[(benzhydrylthio)methyl]-5-methylthiazole

Guidance literature:

With potassium carbonate; In methanol; at 20 ℃; for 48h;

DOI:10.1021/acs.jmedchem.9b01938

upstream raw materials:

5-methyl-1,3-thiazole-2-carbaldehyde

(5-methyl-1,3-thiazol-2-yl)methanol

Refernces

• 1、 -. "SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF". . . Retrieved 2014/09/30.