tert-Butylphenylphosphine oxide

Base Information

• Chemical Name: tert-Butylphenylphosphine oxide
• CAS No.: 98976-30-8
• Molecular Formula: C₁₀H₁₅OP
• Molecular Weight: 182.202
• Mol file: 98976-30-8.mol

Synonyms:

Chemical Property of tert-Butylphenylphosphine oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-Butylphenylphosphine oxide

There total 24 articles about tert-Butylphenylphosphine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

tert-butyl(phenyl)phosphonic acid bromide (128014-09-5) → tert-Butylphenylphosphine oxide (98976-30-8,57956-51-1,6057-79-0,82945-11-7)

Guidance literature:

With ammonia; sodium; In tetrahydrofuran; at -78 ℃; for 0.5h;

DOI:10.1080/10426500008042094

Reference yield: 93.0%

1,2-di-tert-butyl-1,2-diphenyldiphosphane 1,2-dioxide (18351-72-9) → tert-Butylphenylphosphine oxide (98976-30-8,57956-51-1,6057-79-0,82945-11-7)

Guidance literature:

With ammonia; sodium; In tetrahydrofuran; at -78 ℃; for 0.25h;

DOI:10.1080/10426500008042094

Reference yield: 88.0%

tert-butylchlorophenylphosphane (29949-69-7,146387-73-7,146387-74-8) → tert-Butylphenylphosphine oxide (98976-30-8,57956-51-1,6057-79-0,82945-11-7)

Guidance literature:

With water; In tetrahydrofuran; at 20 ℃; for 5h;

DOI:10.1002/chem.201605352

upstream raw materials:

P,P-dichlorophenylphosphine oxide

tert-butylmagnesium chloride

tert-butylchlorophenylphosphane

C₁₇H₁₅OSi^(1-)*K⁽¹⁺⁾

Downstream raw materials:

1,2-di-t-butyl-1,2-diphenyldiphosphane monoxide

t-butylphenylphosphine

(+/-)-tert-butylphenylphosphine borane

C₁₀H₁₄ClP*ClH

Refernces

• 1、 Trost, Barry M.,Spohr, Simon M.,Rolka, Alessa B.,Kalnmals, Christopher A.. "Desymmetrization of Phosphinic Acids via Pd-Catalyzed Asymmetric Allylic Alkylation: Rapid Access to P-Chiral Phosphinates". supporting information. p. 14098 - 14103. Retrieved 2019/10/11.
• 2、 Han, Zhengxu S.,Wu, Hao,Xu, Yibo,Zhang, Yongda,Qu, Bo,Li, Zhibin,Caldwell, Donald R.,Fandrick, Keith R.,Zhang, Li,Roschangar, Frank,Song, Jinhua J.,Senanayake, Chris H.. "General and Stereoselective Method for the Synthesis of Sterically Congested and Structurally Diverse P-Stereogenic Secondary Phosphine Oxides". supporting information. p. 1796 - 1799. Retrieved 2017/04/11.