2-Piperidinonicotinic acid

Base Information

• Chemical Name: 2-Piperidinonicotinic acid
• CAS No.: 78253-61-9
• Molecular Formula: C₁₁H₁₄N₂O₂
• Molecular Weight: 206.244
• Hs Code.: 2933399090
• European Community (EC) Number: 874-042-0
• DSSTox Substance ID: DTXSID50383310
• Nikkaji Number: J2.713.897G
• Wikidata: Q72500870
• Mol file: 78253-61-9.mol

Synonyms:2-Piperidinonicotinic acid;78253-61-9;2-piperidin-1-ylnicotinic acid;2-piperidin-1-ylpyridine-3-carboxylic acid;2-(Piperidin-1-yl)nicotinic acid;2-(piperidin-1-yl)pyridine-3-carboxylic acid;3,4,5,6-Tetrahydro-2H-[1,2']bipyridinyl-3'-carboxylic acid;Oprea1_853419;F2192-0013;SCHEMBL11399275;2-(Piperidin-1-yl)nicotinicacid;DTXSID50383310;MFCD02181988;AKOS000214116;SB43162;2-piperidin-1-ylnicotinic acid, AldrichCPR;FT-0717076;EN300-40286;VU0494926-1;F79907;6Z-0233;Z71176766

Chemical Property of 2-Piperidinonicotinic acid

Chemical Property:

• Melting Point: 102～104℃
• PSA: 53.43000
• LogP: 1.83510
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 206.105527694
• Heavy Atom Count: 15
• Complexity: 227

Purity/Quality:

98%Min ^*data from raw suppliers

2-PiperidinonicotinicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN(CC1)C2=C(C=CC=N2)C(=O)O

Technology Process of 2-Piperidinonicotinic acid

There total 1 articles about 2-Piperidinonicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

piperidine (110-89-4) + 2-chloronicotinic acid (2942-59-8) → 2-(piperidin-1-yl)nicotinic acid (78253-61-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In water; at 200 ℃; for 2h; Microwave irradiation; Biotage Initiator;

DOI:10.1016/j.tetlet.2009.03.034

upstream raw materials:

piperidine

2-chloronicotinic acid

Refernces