N-propylpyridin-2-amine

Base Information

• Chemical Name: N-propylpyridin-2-amine
• CAS No.: 45815-08-5
• Molecular Formula: C8H12N2
• Molecular Weight: 136.197
• DSSTox Substance ID: DTXSID90531959
• Nikkaji Number: J754.679C
• Wikidata: Q72502595
• Mol file: 45815-08-5.mol

Synonyms:N-propylpyridin-2-amine;45815-08-5;2-(PROPYLAMINO)PYRIDINE;2-Propylamino-pyridin;SCHEMBL327850;DTXSID90531959;AKOS008926763

Chemical Property of N-propylpyridin-2-amine

Chemical Property:

• Vapor Pressure: 0.048mmHg at 25°C
• Refractive Index: 1.553
• Boiling Point: 236.056 °C at 760 mmHg
• Flash Point: 96.564 °C
• Density: 1.007 g/cm³
• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 136.100048391
• Heavy Atom Count: 10
• Complexity: 83.3

Purity/Quality:

99% ^*data from raw suppliers

N-propyl-2-Pyridinamine 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCNC1=CC=CC=N1

Technology Process of N-propylpyridin-2-amine

There total 13 articles about N-propylpyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

propyl-pyridin-2-yl-carbamic acid tert-butyl ester (442513-37-3) → 2-(propylamino)pyridine (45815-08-5)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; water;

DOI:10.1021/jo020057z

Reference yield: 86.0%

2-aminopyridine (504-29-0) + propionic acid (802294-64-0,79-09-4) → 2-(propylamino)pyridine (45815-08-5)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; at 40 - 50 ℃; for 0.5h; chemoselective reaction;

DOI:10.3184/174751911X13190991845013

Reference yield: 73.0%

pyridine N-oxide (694-59-7) + propylamine (107-10-8,42939-71-9) → 2-(propylamino)pyridine (45815-08-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In dichloromethane; at 25 ℃; for 15h;

DOI:10.1021/ol102301u

upstream raw materials:

Natrium-Verbindung des [2]Pyridylamins

propyl tosylate

2-aminopyridine

1-iodo-propane

Downstream raw materials:

3-{3-[2-(propyl-pyridin-2-yl-amino)-ethoxy]-phenyl}-propionic acid ethyl ester

C₁₇H₁₆N₂O₂

4-oxo-1-propyl-4H-pyrido[1,2-a]pyrimidinium