4-(2-Pyridyl)-3-thiosemicarbazide

Base Information

• Chemical Name: 4-(2-Pyridyl)-3-thiosemicarbazide
• CAS No.: 36273-89-9
• Molecular Formula: C6H8N4S
• Molecular Weight: 168.222
• Mol file: 36273-89-9.mol

Synonyms:methanone, mercapto(2-pyridinylamino)-, hydrazone, (Z)-;N-pyridin-2-ylcarbamohydrazonothioic acid;N-pyridin-2-ylhydrazinecarbothioamide;

Chemical Property of 4-(2-Pyridyl)-3-thiosemicarbazide

Chemical Property:

• Melting Point: 192-194℃
• Boiling Point: 317.8 °C at 760 mmHg
• Flash Point: 146 °C
• PSA: 102.10000
• Density: 1.406 g/cm³
• LogP: 1.55340

Purity/Quality:

99% ^*data from raw suppliers

3-AMINO-1-(PYRIDIN-2-YL)THIOUREA 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(2-Pyridyl)-3-thiosemicarbazide

There total 9 articles about 4-(2-Pyridyl)-3-thiosemicarbazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

2-aminopyridine (504-29-0) + carbon disulfide (75-15-0,12122-00-8) → 4-(2-pyridyl)-3-thiosemicarbazide (36273-89-9)

Guidance literature:

2-aminopyridine; carbon disulfide; With sodium hydroxide; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

With hydrazine hydrate; In N,N-dimethyl-formamide; at 70 ℃; for 1h;

DOI:10.1080/07391102.2021.1942212

Reference yield: 54.0%

pyridin-2-yl-dithiocarbamic acid methyl ester (13037-46-2) → 4-(2-pyridyl)-3-thiosemicarbazide (36273-89-9)

Guidance literature:

With hydrazine hydrate; In ethanol; at 85 ℃; for 5h;

DOI:10.1016/j.bmcl.2004.02.079

Reference yield:

potassium 2-aminopyridine dithiocarbamate → 4-(2-pyridyl)-3-thiosemicarbazide (36273-89-9)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 1 h / 40 °C

2: hydrazine hydrate / methanol / 0.75 h / Heating

With hydrazine hydrate; In methanol;

DOI:10.1016/j.saa.2006.04.038

upstream raw materials:

pyridin-2-yl-dithiocarbamic acid methyl ester

2-aminopyridine

N-2-pyridinyl-1H-imidazole-1-carbothioamide

carbon disulfide

Downstream raw materials:

N-(α-pyridyl)benzaldehyde thiosemicarbazone

Refernces

• 1、 -. "CHEMICAL ACTIVATORS OF NICOTINAMIDE MONONUCLEOTIDE ADENLYLY TRANSFERASE 2 (NMNAT2) AND USES THEREOF". . . Retrieved 2020/06/22.
• 2、 Mishra,Mishra,Manav,Kumar,Sharad,Chandra,Saluja,Kaushik. "Platinum (IV) thiohydrazide, thiodiamine and thiohydrazone complexes: A spectral, antibacterial and cytotoxic study". . p. 1042 - 1047. Retrieved 2008/02/03.