(2-Amino-5-methylthiophen-3-yl)(4-chlorophenyl)methanone

Base Information

Chemical Name:(2-Amino-5-methylthiophen-3-yl)(4-chlorophenyl)methanone
CAS No.:436093-32-2
Molecular Formula:C₁₂H₁₀ClNOS
Molecular Weight:251.737
Hs Code.:2934999090
DSSTox Substance ID:DTXSID30357675
Wikidata:Q82137690

Synonyms:(2-Amino-5-methylthiophen-3-yl)(4-chlorophenyl)methanone;436093-32-2;(2-amino-5-methylthiophen-3-yl)-(4-chlorophenyl)methanone;ASN 04364361;Oprea1_303948;Oprea1_408034;SCHEMBL21847326;DTXSID30357675;AKOS000707436;3-(4-CHLOROBENZOYL)-5-METHYLTHIOPHEN-2-AMINE

Suppliers and Price of (2-Amino-5-methylthiophen-3-yl)(4-chlorophenyl)methanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
2-Amino-3-chlorobenzoyl-5-methylthiophene
25mg
$ 425.00

Medical Isotopes, Inc.
2-Amino-3-chlorobenzoyl-5-methylthiophene
25 mg
$ 875.00

Crysdot
(2-Amino-5-methylthiophen-3-yl)(4-chlorophenyl)methanone 95+%
1g
$ 2535.00

Chemenu
(2-amino-5-methylthiophen-3-yl)(4-chlorophenyl)methanone 95%
1g
$ 2389.00

Arctom
(2-Amino-5-methylthiophen-3-yl)(4-chlorophenyl)methanone ≥95%
1g
$ 1987.00

Alichem
(2-Amino-5-methylthiophen-3-yl)(4-chlorophenyl)methanone
1g
$ 2129.92

Total 15 raw suppliers

Chemical Property of (2-Amino-5-methylthiophen-3-yl)(4-chlorophenyl)methanone

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:447.453oC at 760 mmHg
PKA:-1.53±0.10(Predicted)
Flash Point:224.412oC
PSA：71.33000
Density:1.342g/cm3
LogP:4.10430
Storage Temp.:2-8°C
Solubility.:Acetone, Dichloromethane, Ether, Ethyl Acetate, Methanol
XLogP3:4.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:251.0171628
Heavy Atom Count:16
Complexity:266

Purity/Quality:

98%min ^*data from raw suppliers

2-Amino-3-chlorobenzoyl-5-methylthiophene ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=C(S1)N)C(=O)C2=CC=C(C=C2)Cl
Uses Intermediate in the preparation of psychotropic drugs

Technology Process of (2-Amino-5-methylthiophen-3-yl)(4-chlorophenyl)methanone

There total 3 articles about (2-Amino-5-methylthiophen-3-yl)(4-chlorophenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 123-38-6
propionaldehyde

: 4640-66-8
p-chlorobenzoylacetonitrile

: 436093-32-2
(2-amino-5-methylthiophen-3-yl)(4-chlorophenyl)methanone

Guidance literature:: With sulfur; diethylamine; In ethanol; at 70 ℃; for 6h;

Reference yield:

: 74-11-3
para-chlorobenzoic acid

: 436093-32-2
(2-amino-5-methylthiophen-3-yl)(4-chlorophenyl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: sulfuric acid / 12 h / 0 °C / Heating; Large scale

2.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 0.5 h / -78 °C

3.1: sulfur; diethylamine / ethanol / 6 h / 70 °C

With sulfuric acid; sulfur; diethylamine; lithium diisopropyl amide; In tetrahydrofuran; ethanol;

Reference yield:

: 1126-46-1
Methyl 4-chlorobenzoate

: 436093-32-2
(2-amino-5-methylthiophen-3-yl)(4-chlorophenyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: 0.5 h / -78 °C

2.1: sulfur; diethylamine / ethanol / 6 h / 70 °C

With sulfur; diethylamine; lithium diisopropyl amide; In tetrahydrofuran; ethanol;