2-AMINO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDIN-4(5H)-ONE

Base Information

• Chemical Name: 2-AMINO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDIN-4(5H)-ONE
• CAS No.: 26493-11-8
• Molecular Formula: C6H7N3OS
• Molecular Weight: 169.20
• Hs Code.: 2934999090
• Mol file: 26493-11-8.mol

Synonyms:2-AMINO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDIN-4(5H)-ONE;Thiazolo[5,4-c]pyridin-4(5H)-one, 2-amino-6,7-dihydro-;2-amino-6,7-dihydro-5H-[1,3]thiazolo[5,4-c]pyridin-4-one

Chemical Property of 2-AMINO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDIN-4(5H)-ONE

Chemical Property:

• Boiling Point: 559.409 °C at 760 mmHg
• PKA: 13.47±0.20(Predicted)
• Flash Point: 292.12 °C
• PSA: 100.47000
• Density: 1.487 g/cm³
• LogP: -0.04830
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99%, ^*data from raw suppliers

2-Amino-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 2-AMINO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDIN-4(5H)-ONE

There total 4 articles about 2-AMINO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDIN-4(5H)-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

tert-butyl 2-amino-4-oxo-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate (1312412-88-6) → 2-amino-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one (26493-11-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 3h;

Reference yield: 68.0%

tert-butyl 3-bromo-2,4-dioxopiperidine-1-carboxylate (1312412-87-5) + thiourea (17356-08-0) → 2-amino-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one (26493-11-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 150 ℃; for 12h;

DOI:10.1016/j.bmcl.2013.05.070

Reference yield:

tert-butyl 2,4-dioxopiperidine-1-carboxylate (845267-78-9) → 2-amino-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one (26493-11-8)

Guidance literature:

Multi-step reaction with 3 steps

1: N-Bromosuccinimide / tetrachloromethane / 2 h / 10 - 15 °C

2: sodium hydrogencarbonate / ethanol / 2.5 h / 80 °C

3: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C

With hydrogenchloride; N-Bromosuccinimide; sodium hydrogencarbonate; In 1,4-dioxane; tetrachloromethane; ethanol;

upstream raw materials:

tert-butyl 2,4-dioxopiperidine-1-carboxylate

tert-butyl 3-bromo-2,4-dioxopiperidine-1-carboxylate

tert-butyl 2-amino-4-oxo-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate

thiourea

Downstream raw materials:

2-bromo-6,7-dihydro-5H-thiazolo[5,4-c]pyridin-4-one

5-methyl-2-phenoxymethyl-6,7-dihydro-5H-thiazolo[5,4-c]pyridin-4-one

C₁₅H₁₂N₂O₂S

C₁₅H₁₂N₂OS

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