5-BROMO-2-[(4-METHOXYCARBONYL)PHENOXY]PYRIMIDINE

Base Information

• Chemical Name: 5-BROMO-2-[(4-METHOXYCARBONYL)PHENOXY]PYRIMIDINE
• CAS No.: 926304-76-9
• Molecular Formula: C12H9 Br N2 O3
• Molecular Weight: 309.119
• Hs Code.: 2933599090
• Mol file: 926304-76-9.mol

Synonyms:4-(5-Bromopyrimidin-2-yloxy)benzoicacid methyl ester

Chemical Property of 5-BROMO-2-[(4-METHOXYCARBONYL)PHENOXY]PYRIMIDINE

Chemical Property:

• Vapor Pressure: 5.48E-08mmHg at 25°C
• Boiling Point: 441.3oC at 760 mmHg
• Flash Point: 220.7oC
• PSA: 61.31000
• Density: 1.541g/cm3
• LogP: 2.81800
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

Methyl4-((5-Bromopyrimidin-2-yl)oxy)benzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-BROMO-2-[(4-METHOXYCARBONYL)PHENOXY]PYRIMIDINE

There total 2 articles about 5-BROMO-2-[(4-METHOXYCARBONYL)PHENOXY]PYRIMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

5-Bromo-2-chloropyrimidine (32779-36-5) + methyl 4-hydroxylbenzoate (99-76-3,156291-94-0) → 4-(5-bromopyrimidin-2-yloxy)benzoic acid methyl ester (926304-76-9)

Guidance literature:

methyl 4-hydroxylbenzoate; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

5-Bromo-2-chloropyrimidine; In N,N-dimethyl-formamide; at 130 ℃; for 0.5h;

Reference yield: 53.0%

3-(5-bromo-pyrimidin-2-yloxy)-3H-[1,2,3]triazolo[4,5-b]pyridine + 4-methoxycarbonylphenylboronic acid (99768-12-4) → 4-(5-bromopyrimidin-2-yloxy)benzoic acid methyl ester (926304-76-9)

Guidance literature:

With dihydrogen peroxide; oxygen; caesium carbonate; In 1,2-dimethoxyethane; water; at 20 ℃; for 10h;

DOI:10.1016/j.tetlet.2009.07.135

Reference yield: 59.0%

4-(5-bromopyrimidin-2-yloxy)benzoic acid methyl ester (926304-76-9) + tri-n-butyl(vinyl)tin (7486-35-3) → 4-(5-vinyl-pyrimidin-2-yloxy)-benzoic acid methyl ester (926304-77-0)

Guidance literature:

With lithium chloride; bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide; at 100 ℃;

upstream raw materials:

4-methoxycarbonylphenylboronic acid

5-Bromo-2-chloropyrimidine

methyl 4-hydroxylbenzoate

Downstream raw materials:

4-(5-vinyl-pyrimidin-2-yloxy)-benzoic acid methyl ester

Refernces

• 1、 Bardhan, Sujata,Wacharasindhu, Sumrit,Wan, Zhao-Kui,Mansour, Tarek S.. "Heteroaryl ethers by oxidative palladium catalysis of pyridotriazol-1-yloxy pyrimidines with arylboronic acids". supporting information; experimental part. p. 2511 - 2514. Retrieved 2009/10/18.
• 2、 -. "CHEMOKINE RECEPTOR BINDING COMPOUNDS". Page/Page column 65. . Retrieved 2010/11/26.