1-(Piperidin-4-yl)pyrrolidin-2-one

Base Information

Chemical Name:1-(Piperidin-4-yl)pyrrolidin-2-one
CAS No.:91596-61-1
Molecular Formula:C9H16N2O
Molecular Weight:168.239
Hs Code.:2933790090
European Community (EC) Number:800-456-8
DSSTox Substance ID:DTXSID60592714
Wikidata:Q72500996
Mol file:91596-61-1.mol

Synonyms:91596-61-1;1-(piperidin-4-yl)pyrrolidin-2-one;1-Piperidin-4-yl-pyrrolidin-2-one;1-piperidin-4-ylpyrrolidin-2-one;1-(4-PIPERIDINYL)-2-PYRROLIDINONE;4-(2-oxo-1-pyrrolidinyl)piperidine;MFCD10700182;2-PYRROLIDINONE, 1-(4-PIPERIDINYL)-;SCHEMBL297012;F2167-0167;DTXSID60592714;CCWNMBJRWFCCOD-UHFFFAOYSA-N;1-(4-Piperidyl)pyrrolidin-2-one;4-(N-2-Pyrrolidinone) piperidine;4-(2-oxopyrrolidin-1-yl)piperidine;1-(piperidin-4-yl)-2-pyrrolidinone;2-Pyrrolidinone,1-(4-piperidinyl)-;4-(2-oxopyrrolidine-1-yl)piperidine;AKOS010951596;SB41319;AS-38229;SY185682;EN300-70135;1-piperidin-4-yl-pyrrolidin-2-one, AldrichCPR;A860313;J-505100;Z839575844

Suppliers and Price of 1-(Piperidin-4-yl)pyrrolidin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-Piperidin-4-yl-pyrrolidin-2-one
2.5g
$ 1320.00

Medical Isotopes, Inc.
1-Piperidin-4-yl-pyrrolidin-2-one
2.5 g
$ 2200.00

Matrix Scientific
1-Piperidin-4-yl-pyrrolidin-2-one 95+%
1g
$ 194.00

Matrix Scientific
1-Piperidin-4-yl-pyrrolidin-2-one 95+%
250mg
$ 145.00

Matrix Scientific
1-Piperidin-4-yl-pyrrolidin-2-one 95+%
500mg
$ 126.00

Crysdot
1-(Piperidin-4-yl)pyrrolidin-2-one 95+%
5g
$ 715.00

Crysdot
1-(Piperidin-4-yl)pyrrolidin-2-one 95+%
1g
$ 260.00

Chemenu
1-Piperidin-4-yl-pyrrolidin-2-one 95%
10g
$ 756.00

Chemenu
1-Piperidin-4-yl-pyrrolidin-2-one 95%
5g
$ 507.00

ChemBridge Corporation
1-(4-piperidinyl)-2-pyrrolidinone 95%
200 μmol
$ 63.00

Total 24 raw suppliers

Chemical Property of 1-(Piperidin-4-yl)pyrrolidin-2-one

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Melting Point:106.2℃
Refractive Index:1.523
Boiling Point:320.169 °C at 760 mmHg
PKA:9.91±0.10(Predicted)
Flash Point:147.433 °C
PSA：32.34000
Density:1.104 g/cm³
LogP:0.62750
Storage Temp.:2-8°C
XLogP3:-0.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:168.126263138
Heavy Atom Count:12
Complexity:175

Purity/Quality:

97% ^*data from raw suppliers

1-Piperidin-4-yl-pyrrolidin-2-one ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(=O)N(C1)C2CCNCC2
Uses 1-Piperidin-4-yl-pyrrolidin-2-one is an azabenzthiazole inhibitor of leukotriene A4 hydrolase. Anti-inflammatory.

Technology Process of 1-(Piperidin-4-yl)pyrrolidin-2-one

There total 5 articles about 1-(Piperidin-4-yl)pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 340962-88-1
1-(1-benzylpiperidin-4-yl)pyrrolidin-2-one

: 91596-61-1
1-(piperidin-4-yl)pyrrolidin-2-one

Guidance literature:: With palladium 10% on activated carbon; ammonium formate; In methanol; for 3h; Reflux;
DOI:10.1021/jm901699j

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 91596-61-1
1-(piperidin-4-yl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: NaCNBH₃; CF₃CH₂OH; 3A sieves

2: H₂ / Pd/C / methanol

With 2,2,2-trifluoroethanol; 3 A molecular sieve; hydrogen; sodium cyanoborohydride; palladium on activated charcoal; In methanol;
DOI:10.1016/S0960-894X(00)00702-2

Reference yield:

: 50541-93-0
4-amino-1-benzylpiperidine

: 91596-61-1
1-(piperidin-4-yl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

2: palladium 10% on activated carbon; hydrogen / ethanol

With palladium 10% on activated carbon; hydrogen; potassium carbonate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.03.050