Technology Process of (4S,6S)-4-(tert-Butyl-diphenyl-silanyloxy)-6-iodomethyl-tetrahydro-pyran-2-one
There total 11 articles about (4S,6S)-4-(tert-Butyl-diphenyl-silanyloxy)-6-iodomethyl-tetrahydro-pyran-2-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: imidazol / CH2Cl2 / 0 °C
2: H2O, Na2CO3 / 25 °C
3: BF3-THF / 6 h / -20 - 0 °C
4: PCC, kieselguhr / CH2Cl2 / 25 °C
5: 93 percent / toluene / 2 h / -15 - 0 °C
6: 99 percent / NaOH / ethanol; H2O / 25 °C
7: I2, NaHCO3 / diethyl ether / 0 °C
With
1H-imidazole; sodium hydroxide; kieselguhr; boron trifluoride-tetrahydrofuran complex; water; iodine; sodium hydrogencarbonate; sodium carbonate; pyridinium chlorochromate;
In
diethyl ether; ethanol; dichloromethane; water; toluene;
DOI:10.1016/S0040-4039(00)86112-2
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 85 percent / HCl gas / 0 °C
2: 91 percent / H2 / Raney-Ni / propan-1-ol; triethylamine / 25 °C
3: H2O / pig liver esterase (PLE) / 30 h / 0 °C / pH 7 (0.3 M aqueous KH2PO4 and 1N NaOH)
4: imidazol / CH2Cl2 / 0 °C
5: H2O, Na2CO3 / 25 °C
6: BF3-THF / 6 h / -20 - 0 °C
7: PCC, kieselguhr / CH2Cl2 / 25 °C
8: 93 percent / toluene / 2 h / -15 - 0 °C
9: 99 percent / NaOH / ethanol; H2O / 25 °C
10: I2, NaHCO3 / diethyl ether / 0 °C
With
1H-imidazole; hydrogenchloride; sodium hydroxide; kieselguhr; boron trifluoride-tetrahydrofuran complex; water; hydrogen; iodine; sodium hydrogencarbonate; sodium carbonate; pyridinium chlorochromate;
pig liver esterase; nickel;
In
propan-1-ol; diethyl ether; ethanol; dichloromethane; water; triethylamine; toluene;
DOI:10.1016/S0040-4039(00)86112-2
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 91 percent / H2 / Raney-Ni / propan-1-ol; triethylamine / 25 °C
2: H2O / pig liver esterase (PLE) / 30 h / 0 °C / pH 7 (0.3 M aqueous KH2PO4 and 1N NaOH)
3: imidazol / CH2Cl2 / 0 °C
4: H2O, Na2CO3 / 25 °C
5: BF3-THF / 6 h / -20 - 0 °C
6: PCC, kieselguhr / CH2Cl2 / 25 °C
7: 93 percent / toluene / 2 h / -15 - 0 °C
8: 99 percent / NaOH / ethanol; H2O / 25 °C
9: I2, NaHCO3 / diethyl ether / 0 °C
With
1H-imidazole; sodium hydroxide; kieselguhr; boron trifluoride-tetrahydrofuran complex; water; hydrogen; iodine; sodium hydrogencarbonate; sodium carbonate; pyridinium chlorochromate;
pig liver esterase; nickel;
In
propan-1-ol; diethyl ether; ethanol; dichloromethane; water; triethylamine; toluene;
DOI:10.1016/S0040-4039(00)86112-2
