1-[Bis(4-fluorophenyl)methyl]-3-azetidinol

Base Information

Chemical Name:1-[Bis(4-fluorophenyl)methyl]-3-azetidinol
CAS No.:116574-15-3
Molecular Formula:C₁₆H₁₅F₂NO
Molecular Weight:275.298
Hs Code.:
DSSTox Substance ID:DTXSID301265050

Synonyms:1-[bis(4-fluorophenyl)methyl]-3-azetidinol;SCHEMBL7275198;DTXSID301265050;116574-15-3

Suppliers and Price of 1-[Bis(4-fluorophenyl)methyl]-3-azetidinol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 1-[Bis(4-fluorophenyl)methyl]-3-azetidinol

Chemical Property:

XLogP3:2.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:275.11217043
Heavy Atom Count:20
Complexity:284

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1C(CN1C(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)O

Technology Process of 1-[Bis(4-fluorophenyl)methyl]-3-azetidinol

There total 1 articles about 1-[Bis(4-fluorophenyl)methyl]-3-azetidinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 55095-27-7
bis(4-fluorophenyl)methanamine

: 106-89-8,24969-06-0,13403-37-7
epichlorohydrin

: 116574-15-3
1-[Bis-(4-fluoro-phenyl)-methyl]-azetidin-3-ol

Guidance literature:: With sodium hydroxide; Yield given. Multistep reaction; 1.) a) RT, 3 d, b) reflux, 72 h, 2.) Et₂O;
DOI:10.1248/cpb.43.797

Reference yield: 20.0%

: 372-09-8
cyanoacetic acid

: 116574-15-3
1-[Bis-(4-fluoro-phenyl)-methyl]-azetidin-3-ol

: 116574-18-6
1-(4,4'-Difluorobenzhydryl)-3-azetidinyl cyanoacetate

Guidance literature:: With dicyclohexyl-carbodiimide; In tetrahydrofuran; at 55 ℃;
DOI:10.1248/cpb.43.797

Reference yield:

: 116574-15-3
1-[Bis-(4-fluoro-phenyl)-methyl]-azetidin-3-ol

: Ethoxycarbonimidoyl-acetic acid 1-[bis-(4-fluoro-phenyl)-methyl]-azetidin-3-yl ester; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 20 percent / dicyclohexylcarbodiimide / tetrahydrofuran / 55 °C

2: HCl(g) / CHCl₃

With hydrogenchloride; dicyclohexyl-carbodiimide; In tetrahydrofuran; chloroform;
DOI:10.1248/cpb.43.797