N-carbobenzoxy-L-prolyl-L-leucine chloro-2 ethylamide

Base Information

• Chemical Name: N-carbobenzoxy-L-prolyl-L-leucine chloro-2 ethylamide
• CAS No.: 83472-44-0
• Molecular Formula: C₂₁H₃₀ClN₃O₄
• Molecular Weight: 423.94
• Mol file: 83472-44-0.mol

Synonyms:

Chemical Property of N-carbobenzoxy-L-prolyl-L-leucine chloro-2 ethylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of N-carbobenzoxy-L-prolyl-L-leucine chloro-2 ethylamide

There total 3 articles about N-carbobenzoxy-L-prolyl-L-leucine chloro-2 ethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Z-L-leucine hydroxysuccinimide ester (3397-35-1) → N-carbobenzoxy-L-prolyl-L-leucine chloro-2 ethylamide (83472-44-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 87 percent / N,N-diisopropyl N-ethylamine / dimethylformamide / 2 h / Ambient temperature

2: H₂, cc. HCl / Pd/C / ethanol / 5 h

3: N,N-diisopropyl N-ethylamine / dimethylformamide / 2 h / Ambient temperature

With hydrogenchloride; hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;

Reference yield:

N-benzyloxycarbonylleucine (2-chloroethyl)amide (83510-60-5) → N-carbobenzoxy-L-prolyl-L-leucine chloro-2 ethylamide (83472-44-0)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂, cc. HCl / Pd/C / ethanol / 5 h

2: N,N-diisopropyl N-ethylamine / dimethylformamide / 2 h / Ambient temperature

With hydrogenchloride; hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;

Reference yield:

Z-proline N-hydroxysuccinimide ester (3397-33-9) + (S)-2-Amino-4-methyl-pentanoic acid (2-chloro-ethyl)-amide; hydrochloride (4815-82-1,92673-17-1) → N-carbobenzoxy-L-prolyl-L-leucine chloro-2 ethylamide (83472-44-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 2h; Yield given; Ambient temperature;

upstream raw materials:

Z-proline N-hydroxysuccinimide ester

(S)-2-Amino-4-methyl-pentanoic acid (2-chloro-ethyl)-amide; hydrochloride

Z-L-leucine hydroxysuccinimide ester

N-benzyloxycarbonylleucine (2-chloroethyl)amide

Downstream raw materials:

N-(chloro-2-ethyl) N-nitrosocarbamoyl L-prolyl L-leucine chloro-2 ethylamide

N-methyl-N-nitrosocarbamoyl L-prolyl L-leucine chloro-2 ethylamide