5'-O-4,4'-dimethoxytrityl-6-N-benzoyl-2'-deoxyadenylyl-(3'-6')-<1-(2',3'-dideoxy-4'-O-acetyl-β-D-erythro-hex-2'-enopyranosyl)thymine>p-chlorophenyl phosphate

Base Information

Chemical Name:5'-O-4,4'-dimethoxytrityl-6-N-benzoyl-2'-deoxyadenylyl-(3'-6')-<1-(2',3'-dideoxy-4'-O-acetyl-β-D-erythro-hex-2'-enopyranosyl)thymine>p-chlorophenyl phosphate
CAS No.:162757-32-6
Molecular Formula:C₅₇H₅₃ClN₇O₁₄P
Molecular Weight:1126.51
Hs Code.:

5'-O-4,4'-dimethoxytrityl-6-N-benzoyl-2'-deoxyadenylyl-(3'-6')-<1-(2',3'-dideoxy-4'-O-acetyl-β-D-erythro-hex-2'-enopyranosyl)thymine>p-chlorophenyl phosphate

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Chemical Property of 5'-O-4,4'-dimethoxytrityl-6-N-benzoyl-2'-deoxyadenylyl-(3'-6')-<1-(2',3'-dideoxy-4'-O-acetyl-β-D-erythro-hex-2'-enopyranosyl)thymine>p-chlorophenyl phosphate

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Technology Process of 5'-O-4,4'-dimethoxytrityl-6-N-benzoyl-2'-deoxyadenylyl-(3'-6')-<1-(2',3'-dideoxy-4'-O-acetyl-β-D-erythro-hex-2'-enopyranosyl)thymine>p-chlorophenyl phosphate

There total 4 articles about 5'-O-4,4'-dimethoxytrityl-6-N-benzoyl-2'-deoxyadenylyl-(3'-6')-<1-(2',3'-dideoxy-4'-O-acetyl-β-D-erythro-hex-2'-enopyranosyl)thymine>p-chlorophenyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 64750-95-4
1-(2',3'-dideoxy-β-D-erythro-hex-2'-enopyranosyl)thymine

: 162757-32-6
5'-O-4,4'-dimethoxytrityl-6-N-benzoyl-2'-deoxyadenylyl-(3'-6')-<1-(2',3'-dideoxy-4'-O-acetyl-β-D-erythro-hex-2'-enopyranosyl)thymine>p-chlorophenyl phosphate

Guidance literature:: Multi-step reaction with 4 steps

1: 4-(dimethylmino)pyridine / CH₂Cl₂; pyridine / 10 h

2: CH₂Cl₂; pyridine / 10 h

3: AcOH / H₂O

4: 2,4,6-triisopropylbenzenesulfonyl chloride, 1H-tetrazole / pyridine / 24 h

With 1H-tetrazole; dmap; 2,4,6-triisopropylphenylsulfonyl chloride; acetic acid; In pyridine; dichloromethane; water;
DOI:10.1080/15257779508014661

Reference yield:

: 64325-78-6
N₆-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine

: 162757-32-6
5'-O-4,4'-dimethoxytrityl-6-N-benzoyl-2'-deoxyadenylyl-(3'-6')-<1-(2',3'-dideoxy-4'-O-acetyl-β-D-erythro-hex-2'-enopyranosyl)thymine>p-chlorophenyl phosphate

Guidance literature:: Multi-step reaction with 2 steps

1: 2,4,6-triisopropylbenzenesulfonyl chloride / pyridine / 4 h

2: 2,4,6-triisopropylbenzenesulfonyl chloride, 1H-tetrazole / pyridine / 24 h

With 1H-tetrazole; 2,4,6-triisopropylphenylsulfonyl chloride; In pyridine;
DOI:10.1080/15257779508014661

Reference yield:

: p-chlorophenyl phosphate

: 162757-32-6
5'-O-4,4'-dimethoxytrityl-6-N-benzoyl-2'-deoxyadenylyl-(3'-6')-<1-(2',3'-dideoxy-4'-O-acetyl-β-D-erythro-hex-2'-enopyranosyl)thymine>p-chlorophenyl phosphate

Guidance literature:: Multi-step reaction with 2 steps

1: 2,4,6-triisopropylbenzenesulfonyl chloride / pyridine / 4 h

2: 2,4,6-triisopropylbenzenesulfonyl chloride, 1H-tetrazole / pyridine / 24 h

With 1H-tetrazole; 2,4,6-triisopropylphenylsulfonyl chloride; In pyridine;
DOI:10.1080/15257779508014661