Ethyl 2-phenyl-1H-azuleno[2,1-b]pyrrole-9-carboxylate

Base Information

Chemical Name:Ethyl 2-phenyl-1H-azuleno[2,1-b]pyrrole-9-carboxylate
CAS No.:78156-42-0
Molecular Formula:C₂₁H₁₇NO₂
Molecular Weight:315.371
Hs Code.:
DSSTox Substance ID:DTXSID401214393

Synonyms:Ethyl 2-phenyl-1H-azuleno[2,1-b]pyrrole-9-carboxylate;DTXSID401214393;78156-42-0

Suppliers and Price of Ethyl 2-phenyl-1H-azuleno[2,1-b]pyrrole-9-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Ethyl 2-phenyl-1H-azuleno[2,1-b]pyrrole-9-carboxylate

Chemical Property:

XLogP3:4.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:315.125928785
Heavy Atom Count:24
Complexity:445

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C1=C2C=CC=CC=C2C3=C1NC(=C3)C4=CC=CC=C4

Technology Process of Ethyl 2-phenyl-1H-azuleno[2,1-b]pyrrole-9-carboxylate

There total 5 articles about Ethyl 2-phenyl-1H-azuleno[2,1-b]pyrrole-9-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 13146-23-1
copper(I) phenylacetylenide

: 76279-84-0
ethyl 2-acetylamino-3-iodoazulene-1-carboxylate

: 78156-42-0
ethyl 2-phenyl-3H-azuleno[2,1-b]pyrrole-4-carboxylate

Guidance literature:: With pyridine; for 6h; Heating;

Reference yield:

: 1454276-29-9
ethyl 2-acetylamino-3-phenylethynylazulene-1-carboxylate

: 78156-42-0
ethyl 2-phenyl-3H-azuleno[2,1-b]pyrrole-4-carboxylate

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; triethylamine; In N,N-dimethyl-formamide; at 100 ℃; for 24h; Reagent/catalyst;
DOI:10.3987/COM-12-S(N)4

Reference yield:

: 76279-83-9
ethyl 2-acetylaminoazulene-1-carboxylate

: 78156-42-0
ethyl 2-phenyl-3H-azuleno[2,1-b]pyrrole-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: N-iodo-succinimide / dichloromethane / 0.25 h / 5 °C

2: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

3: triethylamine; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 24 h / 100 °C

With bis-triphenylphosphine-palladium(II) chloride; N-iodo-succinimide; copper(l) iodide; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 2: |Sonogashira Cross-Coupling;
DOI:10.3987/COM-12-S(N)4