2,4,7-Trichloropyrido[2,3-d]pyrimidine

Base Information

Chemical Name:2,4,7-Trichloropyrido[2,3-d]pyrimidine
CAS No.:938443-20-0
Molecular Formula:C7H2 Cl3 N3
Molecular Weight:234.472
Hs Code.:2933990090
Mol file:938443-20-0.mol

Synonyms:2,4,7-trichloropyrido[2,3-d]pyrimidine

Suppliers and Price of 2,4,7-Trichloropyrido[2,3-d]pyrimidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2,4,7-Trichloropyrido[2,3-d]pyrimidine
1g
$ 1055.00

TRC
2,4,7-Trichloropyrido[2,3-d]pyrimidine
100mg
$ 130.00

SynQuest Laboratories
2,4,7-Trichloropyrido[2,3-d]pyrimidine
250 mg
$ 325.00

Sigma-Aldrich
2,4,7-Trichloropyrido[2,3-d]pyrimidine Aldrich
1g
$ 1250.00

Medical Isotopes, Inc.
2,4,7-Trichloropyrido[2,3-d]pyrimidine
100 mg
$ 620.00

Medical Isotopes, Inc.
2,4,7-Trichloropyrido[2,3-d]pyrimidine
1 g
$ 1460.00

Matrix Scientific
2,4,7-Trichloropyrido[2,3-d]pyrimidine 95%
250mg
$ 115.00

Crysdot
2,4,7-Trichloropyrido[2,3-d]pyrimidine 95+%
1g
$ 285.00

Chemenu
2,4,7-trichloropyrido[2,3-d]pyrimidine 95%+
1g
$ 269.00

American Custom Chemicals Corporation
2,4,7-TRICHLOROPYRIDO[2,3-D]PYRIMIDINE 95.00%
1G
$ 3164.70

Total 51 raw suppliers

Chemical Property of 2,4,7-Trichloropyrido[2,3-d]pyrimidine

Chemical Property:

Refractive Index:1.688
Boiling Point:316.4±42.0 °C(Predicted)
PKA:-2.53±0.30(Predicted)
PSA：38.67000
Density:1.686 g/cm³
LogP:2.98500
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

2,4,7-Trichloropyrido[2,3-d]pyrimidine ^*data from reagent suppliers

Safty Information:

Pictogram(s): T
Hazard Codes:T
Statements: 25-41
Safety Statements: 26-39-45

MSDS Files:: SDS file from LookChem

Useful:

Uses 2,4,7-Trichloropyrido[2,3-d]pyrimidine is used in the synthetic preparation of dual mTORC1/mTORC2 inhibitors and the discovery of AZD8055 and AZD2014 as potential antitumor agents.

Technology Process of 2,4,7-Trichloropyrido[2,3-d]pyrimidine

There total 8 articles about 2,4,7-Trichloropyrido[2,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 938443-20-0
2,4,7-trichloropyrido[2,3-d]pyrimidine

Guidance literature:

Reference yield: 48.0%

: 938443-19-7
7-chloropyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione

: 938443-20-0
2,4,7-trichloropyrido[2,3-d]pyrimidine

Guidance literature:: 7-chloropyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione; With N-ethyl-N,N-diisopropylamine; In toluene; at 70 ℃; for 0.5h;

With trichlorophosphate; In toluene; at 20 - 100 ℃; for 2.5h;

Reference yield:

: 64321-24-0
2-amino-6-chloro-pyridine-3-carboxamide

: 938443-20-0
2,4,7-trichloropyrido[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: toluene / 115 °C

2: trichlorophosphate; N-ethyl-N,N-diisopropylamine / toluene / 100 °C

With N-ethyl-N,N-diisopropylamine; trichlorophosphate; In toluene;
DOI:10.1016/j.bmcl.2013.01.019