Chemical Property of Deoxyarbutin
Chemical Property:
- Melting Point:83-88℃
- Boiling Point:349.779 °C at 760 mmHg
- PKA:10.10±0.15(Predicted)
- Flash Point:165.341 °C
- PSA：38.69000
- Density:1.174 g/cm3
- LogP:2.29760
- Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
- Solubility.:Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Sonicated)
- XLogP3:2.4
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:3
- Rotatable Bond Count:2
- Exact Mass:194.094294304
- Heavy Atom Count:14
- Complexity:164
- Purity/Quality:
-
99%, *data from raw suppliers
Deoxyarbutin *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C1CCOC(C1)OC2=CC=C(C=C2)O
-
Description
Deoxyarbutin is a tyrosinase inhibitor (IC50 = 17.5 μM for mushroom tyrosinase). It reduces melanin content in isolated dark human melanocytes when used at a concentration of 1.56 μM. Topical administration of deoxyarbutin (5%) induces skin lightening in human skin mouse xenograft models. Deoxyarbutin also inhibits proliferation of B16/F10 murine melanoma cells (EC50 = 39.56 μM). It induces apoptosis and halts the cell cycle at the S phase in B16/F10 cells when used at a concentration of 50 μM. Deoxyarbutin (50 mg/kg) reduces tumor growth in a B16/F10 murine melanoma model.
-
Uses
Deoxyarbutin acts as a skin whitening agent through the inhibition of tyrosinase. A safer alternative to the use of hydroquinone and arbutin.
