Tetrahydro-2-[4-(phenylmethoxy)phenoxy]-2H-pyran

Base Information

• Chemical Name: Tetrahydro-2-[4-(phenylmethoxy)phenoxy]-2H-pyran
• CAS No.: 53936-79-1
• Molecular Formula: C₁₈H₂₀O₃
• Molecular Weight: 284.355
• DSSTox Substance ID: DTXSID501239300
• Mol file: 53936-79-1.mol

Synonyms:SCHEMBL8601010;DTXSID501239300;53936-79-1;Tetrahydro-2-[4-(phenylmethoxy)phenoxy]-2H-pyran

Chemical Property of Tetrahydro-2-[4-(phenylmethoxy)phenoxy]-2H-pyran

Chemical Property:

• XLogP3: 4.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 284.14124450
• Heavy Atom Count: 21
• Complexity: 280

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CCOC(C1)OC2=CC=C(C=C2)OCC3=CC=CC=C3

Technology Process of Tetrahydro-2-[4-(phenylmethoxy)phenoxy]-2H-pyran

There total 1 articles about Tetrahydro-2-[4-(phenylmethoxy)phenoxy]-2H-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3,4-dihydro-2H-pyran (110-87-2) + 4-Benzyloxyphenol (103-16-2) → 4-benzyloxyphenyl 2-tetrahydropyranyl ether (53936-79-1)

Guidance literature:

With pyridinium p-toluenesulfonate; In dichloromethane; at 20 ℃; for 8h; Inert atmosphere; Cooling with ice;

Reference yield: 100.0%

4-benzyloxyphenyl 2-tetrahydropyranyl ether (53936-79-1) → 4-(tetrahydro-2H-2-pyranyloxy)phenol (53936-56-4)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In ethanol; at 20 ℃; for 3h; under 3000.3 Torr; Autoclave;

Reference yield: 90.0%

4-benzyloxyphenyl 2-tetrahydropyranyl ether (53936-79-1) → 4-Benzyloxyphenol (103-16-2)

Guidance literature:

With aluminium(III) iodide; N,N-dimethyl-formamide dimethyl acetal; In acetonitrile; at 20 ℃; for 2h;

DOI:10.1021/acs.joc.0c00290

upstream raw materials:

3,4-dihydro-2H-pyran

4-Benzyloxyphenol

Downstream raw materials:

4-(tetrahydro-2H-2-pyranyloxy)phenol

C₁₇H₂₆O₄

6-[(4-hydroxyphenyl)oxy]hexyl acrylate