Technology Process of 7-(2,4,6-Trimethylphenyl)-N,N,2-triethylpyrazolo[1,5-a]pyridin-3-amine
There total 4 articles about 7-(2,4,6-Trimethylphenyl)-N,N,2-triethylpyrazolo[1,5-a]pyridin-3-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: calcium chloride; zinc / ethanol; water / 2 h / Heating / reflux
2: sodium cyanoborohydride / acetonitrile / 72 h / 20 °C
3: n-butyllithium / tetrahydrofuran; hexane / 3.5 h / -78 °C
4: potassium phosphate; mesitylboronic acid / tris-(dibenzylideneacetone)dipalladium(0) / toluene / 114 h / Heating / reflux
With
potassium phosphate; n-butyllithium; mesitylboronic acid; sodium cyanoborohydride; calcium chloride; zinc;
tris-(dibenzylideneacetone)dipalladium(0);
In
tetrahydrofuran; ethanol; hexane; water; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: ammonium nitrate; sulfuric acid / 2 h / -5 - 0 °C
2: calcium chloride; zinc / ethanol; water / 2 h / Heating / reflux
3: sodium cyanoborohydride / acetonitrile / 72 h / 20 °C
4: n-butyllithium / tetrahydrofuran; hexane / 3.5 h / -78 °C
5: potassium phosphate; mesitylboronic acid / tris-(dibenzylideneacetone)dipalladium(0) / toluene / 114 h / Heating / reflux
With
ammonium nitrate; potassium phosphate; n-butyllithium; sulfuric acid; mesitylboronic acid; sodium cyanoborohydride; calcium chloride; zinc;
tris-(dibenzylideneacetone)dipalladium(0);
In
tetrahydrofuran; ethanol; hexane; water; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium cyanoborohydride / acetonitrile / 72 h / 20 °C
2: n-butyllithium / tetrahydrofuran; hexane / 3.5 h / -78 °C
3: potassium phosphate; mesitylboronic acid / tris-(dibenzylideneacetone)dipalladium(0) / toluene / 114 h / Heating / reflux
With
potassium phosphate; n-butyllithium; mesitylboronic acid; sodium cyanoborohydride;
tris-(dibenzylideneacetone)dipalladium(0);
In
tetrahydrofuran; hexane; toluene; acetonitrile;