274-56-6

Basic information

• Product Name: Pyrazolo[1,5-a]pyridine
• Synonyms: PYRAZOLO[1,5-A]PYRIDINE;3-Azaindoline;1H-Pyrazolo[1,5-a]pyridine
• CAS NO: 274-56-6
• Molecular Formula: C₇H₆N₂
• Molecular Weight: 118.14
• Mol File: 274-56-6.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 37-39℃/0.2mm
• Flash Point: °C
• Appearance: Colorless to red or brown/Liquid
• Density: 1.14g/cm³
• Refractive Index: 1.6075
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 2.83±0.30(Predicted)
• CAS DataBase Reference: Pyrazolo[1,5-a]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrazolo[1,5-a]pyridine(274-56-6)
• EPA Substance Registry System: Pyrazolo[1,5-a]pyridine(274-56-6)

Safety Data

• Hazardous Substances Data: 274-56-6(Hazardous Substances Data)

Usage

General Description

Pyrazolo[1,5-a]pyridine is a type of organic compound classified under the family of azolo[4,5-b]pyridines. This polycyclic heterocyclic aromatic compound is recognized by its unique structure which includes a pyrazole ring connected to a pyridine ring. Primarily used in research, Pyrazolo[1,5-a]pyridine has been found to have diverse biological activities. For instance, it is used as an intermediate in synthesizing various pharmaceuticals, as well as developing countless biologically active molecules for medicinal chemistry.

InChI:InChI=1/C7H6N2/c1-2-6-9-7(3-1)4-5-8-9/h1-6H

Upstream product

• 2706-56-1 2-(aminoethyl)pyridine 
• 76943-40-3 N-amino-2-ethynylpyridinium mesitylenesulfonate 
• 16205-46-2 pyrazolo[1,5-a]pyridine-3-carboxylic acid 
• 101933-27-1 (E)-β-phenylthionitroethylene 
• 16205-44-0 Pyrazolo<1,5-a>pyridin-3-carbonsaeureethylester 
• 1207557-48-9 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl)pyrazolo[1,5-a]pyridine 
• 5750-76-5 2,4,5-trichloropyrimidine 
• 19363-99-6 3-iodopyrazolo[1,5-a]pyridine 
• 63237-84-3 methyl pyrazolo<1,5-a>pyridine-3-carboxylate 
• 108-86-1 bromobenzene 
• 45458-31-9 N-Aminopyridinium 

Downstream Products

• 143307-85-1 α-<3-(trifluoromethyl)phenyl>pyrazolo<1,5-a>pyridine-7-methanol 
• 115748-38-4 phenylbis(pyrazolo<1,5-a>pyrid-3-yl)methane 
• 19364-00-2 1-Benzoylpyrazolo<1,5-a>pyridine 
• 59942-95-9 1-Acetylpyrazolo<1,5-a>pyridine 
• 73957-66-1 3-pyrazolo<1,5-a>pyridineacarboxaldehyde 
• 362661-83-4 pyrazolo[1,5-a]pyridine-7-carboxaldehyde 
• 511255-05-3 N-pyrazolo[1,5-a]pyridin-3-ylmethyl-L-proline-4-chlorophenylamide 
• 319432-36-5 pyrazolo[1,5-a]pyridine-7-carbonitrile 
• 319432-24-1 7-Phenylpyrazolo[1,5-a]pyridine 
• 319432-30-9 7-(4-Fluorophenyl)pyrazolo[1,5-a]pyridine 
• 319432-38-7 7-(4-Benzylpiperazin-1-yl)pyrazolo[1,5-a]pyridine 
• 19363-97-4 1-nitropyrazolo<5,1-a>pyridine 
• 63139-06-0 1-benzylpyrazolo[1,5-a]pyridinium bromide 
• 1016167-58-0 C₂₀H₂₃FN₄O 

Relevant articles and documents

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Pyrido[1',2':1,5]pyrazolo[4,3-b]quinolines as New Fluorescent Heterocyclic Systems for Dye-Sensitized Solar Cells

Abstract: New fluorescent heterocyclic compounds pyrido[1',2':1,5]pyrazolo[4,3-b]quinolines have been synthesized by the reaction of 3-nitropyrazolo[1,5-a]pyridine with different arylacetonitriles in high yield. Structural assignments of the new compounds

Regioselective Metalation and Functionalization of the Pyrazolo[1,5- a]pyridine Scaffold Using Mg- and Zn-TMP Bases

A regioselective functionalization of the pyrazolo[1,5-a]pyridine scaffold using Mg- and Zn-TMP bases (TMP = 2,2,6,6-tetramethylpiperidyl) in the presence or absence of BF3·OEt2 is described. Also, various functionalized pyrazolo[1,5-a]pyridines bearing an ester function (and an NHBoc or ethyl group) are magnesiated and functionalized, leading to polysubstituted heterocycles. Additionally, a sulfoxide directed ortho-metalation, followed by the transition-metal-free amination of a pyrazolo[1,5-a]pyridine sulfoxide, using a magnesium amide, is reported.