1-Boc-4-bromo-3-hydroxymethylindole

Base Information

• Chemical Name: 1-Boc-4-bromo-3-hydroxymethylindole
• CAS No.: 914349-05-6
• Molecular Formula: C₁₄H₁₆BrNO₃
• Molecular Weight: 326.19
• Hs Code.: 2933990090
• Mol file: 914349-05-6.mol

Synonyms:OR1688;1-Boc-4-Bromo-3-hydroxymethylindole;

Chemical Property of 1-Boc-4-bromo-3-hydroxymethylindole

Chemical Property:

• Vapor Pressure: 1.36E-08mmHg at 25°C
• Boiling Point: 442.1oC at 760 mmHg
• Flash Point: 221.2oC
• PSA: 51.46000
• Density: 1.42g/cm3
• LogP: 3.67930

Purity/Quality:

97% ^*data from raw suppliers

1-Boc-4-Bromo-3-hydroxymethylindole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Boc-4-bromo-3-hydroxymethylindole

There total 4 articles about 1-Boc-4-bromo-3-hydroxymethylindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-bromo-1-tert-butoxycarbonylindole-3-carboxaldehyde (303041-88-5) → tert-butyl 4-bromo-3-(hydroxymethyl)-1H-indole-1-carboxylate (914349-05-6)

Guidance literature:

With sodium hydride; In deuteromethanol; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/acs.joc.5b02815

Reference yield: 60.0%

→ tert-butyl 4-bromo-3-(hydroxymethyl)-1H-indole-1-carboxylate (914349-05-6)

Guidance literature:

With sodium tetrahydroborate; ethanol;

Reference yield:

4-bromo-1H-indole (52488-36-5) → tert-butyl 4-bromo-3-(hydroxymethyl)-1H-indole-1-carboxylate (914349-05-6)

Guidance literature:

Multi-step reaction with 3 steps

1: trichlorophosphate / Inert atmosphere

2: dmap / acetonitrile / Inert atmosphere

3: sodium hydride / deuteromethanol / 0 - 20 °C / Inert atmosphere

With dmap; sodium hydride; trichlorophosphate; In deuteromethanol; acetonitrile;

DOI:10.1021/acs.joc.5b02815

upstream raw materials:

4-bromo-1H-indole

4-bromo-1H-indole-3-carbaldehyde

4-bromo-1-tert-butoxycarbonylindole-3-carboxaldehyde

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 914349-05-6 1-Boc-4-bromo-3-hydroxymethylindole

Send

Send

Metric Ton KG G Pound L ML

Send

Send