(R)-1-(TERT-BUTOXYCARBONYL)PIPERIDIN-3-YL METHANESULFONATE

Base Information

• Chemical Name: (R)-1-(TERT-BUTOXYCARBONYL)PIPERIDIN-3-YL METHANESULFONATE
• CAS No.: 404577-34-0
• Molecular Formula: C11H21NO5S
• Molecular Weight: 279.357
• Hs Code.: 2933399090
• Mol file: 404577-34-0.mol

Synonyms:(R)-1-(TERT-BUTOXYCARBONYL)PIPERIDIN-3-YL METHANESULFONATE;(R)-1-N-Boc-3-methanesulfonyloxypiperidine

Chemical Property of (R)-1-(TERT-BUTOXYCARBONYL)PIPERIDIN-3-YL METHANESULFONATE

Chemical Property:

• Boiling Point: 407.2 °C at 760 mmHg
• Flash Point: 200.1 °C
• PSA: 81.29000
• Density: 1.22 g/cm³
• LogP: 2.38080
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

(R)-1-N-Boc-3-Methanesulfonyloxypiperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-1-(TERT-BUTOXYCARBONYL)PIPERIDIN-3-YL METHANESULFONATE

There total 13 articles about (R)-1-(TERT-BUTOXYCARBONYL)PIPERIDIN-3-YL METHANESULFONATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanesulfonyl chloride (124-63-0) + tert-butyl (3R)-3-hydroxypiperidine-1-carboxylate (143900-43-0) → (R)-3-methanesulfonyloxy-piperidine-1-carboxylic acid tert-butyl ester (404577-34-0)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 2.5h; Product distribution / selectivity;

Reference yield:

tert-butyl (3R)-3-hydroxypiperidine-1-carboxylate (143900-43-0) → (R)-3-methanesulfonyloxy-piperidine-1-carboxylic acid tert-butyl ester (404577-34-0) + 14-O-[(N-(3-Methyl-2-amino-buturyl-piperidin-3-yl)sulfanyl)acetyl]mutilin

Guidance literature:

In pyridine; dichloromethane;

Reference yield:

1-benzyl-3-hydroxypiperidine (14813-01-5) → (R)-3-methanesulfonyloxy-piperidine-1-carboxylic acid tert-butyl ester (404577-34-0)

Guidance literature:

Multi-step reaction with 4 steps

1: isopropyl alcohol / 1 h / 20 °C

2: sodium hydroxide / dichloromethane / 1 h / 20 °C

3: palladium 10% on activated carbon; hydrogen / methanol / 15 h / 60 °C / 3800.26 Torr / Autoclave

4: triethylamine / dichloromethane / 1 h / 0 - 20 °C

With palladium 10% on activated carbon; hydrogen; triethylamine; sodium hydroxide; In methanol; dichloromethane; isopropyl alcohol;

upstream raw materials:

methanesulfonyl chloride

tert-butyl (3R)-3-hydroxypiperidine-1-carboxylate

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

di-tert-butyl dicarbonate

Downstream raw materials:

N-Boc-1,2,3,6-tetrahydropyridine

(R)-3-(3-fluoro-phenoxy)-piperidine

(S)-3-(3-fluoro-phenoxy)-piperidine

C₁₇H₂₅NO₃

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