tert-butyl {4-[2-(bis-tert-butyoxycarbonylmethylamino)-3-(4-succinylamidophenyl)propyl]-7-tert-butyoxycarbonylmethyl-[1,4,7]triazacyclononan-1-yl}acetate

Base Information

Chemical Name:tert-butyl {4-[2-(bis-tert-butyoxycarbonylmethylamino)-3-(4-succinylamidophenyl)propyl]-7-tert-butyoxycarbonylmethyl-[1,4,7]triazacyclononan-1-yl}acetate
CAS No.:1161415-25-3
Molecular Formula:C₄₃H₇₁N₅O₁₁
Molecular Weight:834.064
Hs Code.:

tert-butyl {4-[2-(bis-tert-butyoxycarbonylmethylamino)-3-(4-succinylamidophenyl)propyl]-7-tert-butyoxycarbonylmethyl-[1,4,7]triazacyclononan-1-yl}acetate

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Chemical Property of tert-butyl {4-[2-(bis-tert-butyoxycarbonylmethylamino)-3-(4-succinylamidophenyl)propyl]-7-tert-butyoxycarbonylmethyl-[1,4,7]triazacyclononan-1-yl}acetate

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Technology Process of tert-butyl {4-[2-(bis-tert-butyoxycarbonylmethylamino)-3-(4-succinylamidophenyl)propyl]-7-tert-butyoxycarbonylmethyl-[1,4,7]triazacyclononan-1-yl}acetate

There total 1 articles about tert-butyl {4-[2-(bis-tert-butyoxycarbonylmethylamino)-3-(4-succinylamidophenyl)propyl]-7-tert-butyoxycarbonylmethyl-[1,4,7]triazacyclononan-1-yl}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 108-30-5
succinic acid anhydride

: 1041634-48-3
C₃₉H₆₇N₅O₈

: 1161415-25-3
tert-butyl {4-[2-(bis-tert-butyoxycarbonylmethylamino)-3-(4-succinylamidophenyl)propyl]-7-tert-butyoxycarbonylmethyl-[1,4,7]triazacyclononan-1-yl}acetate

Guidance literature:: In acetonitrile; for 3h;
DOI:10.1021/bc100137x

Reference yield:

: 1161415-25-3
tert-butyl {4-[2-(bis-tert-butyoxycarbonylmethylamino)-3-(4-succinylamidophenyl)propyl]-7-tert-butyoxycarbonylmethyl-[1,4,7]triazacyclononan-1-yl}acetate

: DUPA-EAOA-Phe-Phe-EDA-NH₂

: DUPA-C-NETA

Guidance literature:: tert-butyl {4-[2-(bis-tert-butyoxycarbonylmethylamino)-3-(4-succinylamidophenyl)propyl]-7-tert-butyoxycarbonylmethyl-[1,4,7]triazacyclononan-1-yl}acetate; DUPA-EAOA-Phe-Phe-EDA-NH₂; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;

With trifluoroacetic acid;

Reference yield:

: 1193642-32-8
Alloc-D-Lys(Fmoc)-OH

: Trt-HSG-OH

: 1161415-25-3
tert-butyl {4-[2-(bis-tert-butyoxycarbonylmethylamino)-3-(4-succinylamidophenyl)propyl]-7-tert-butyoxycarbonylmethyl-[1,4,7]triazacyclononan-1-yl}acetate

: 35661-38-2,35661-39-3,79990-15-1,136132-75-7
N-(9-fluorenylmethoxycarbonyl)-D-alanine

: 118488-18-9,204384-67-8
Fmoc-D-Tyr(O-tBu)-OH

: C-NETA-succinyl-D-Lys(HSG)-D-Tyr-D-Lys(HSG)-NH₂

Guidance literature:: Alloc-D-Lys(Fmoc)-OH; With Sieber amide resin; condensing agent; solid phase reaction;

With Fmoc deprotecting agent; solid phase reaction;

Alloc-D-Lys(Fmoc)-OH; Trt-HSG-OH; tert-butyl {4-[2-(bis-tert-butyoxycarbonylmethylamino)-3-(4-succinylamidophenyl)propyl]-7-tert-butyoxycarbonylmethyl-[1,4,7]triazacyclononan-1-yl}acetate; N-(9-fluorenylmethoxycarbonyl)-D-alanine; Fmoc-D-Tyr(O-tBu)-OH; Further stages;
DOI:10.1021/bc100137x