C₆₁H₈₀N₂O₁₃Si

Base Information

• Chemical Name: C₆₁H₈₀N₂O₁₃Si
• CAS No.: 885674-97-5
• Molecular Formula: C₆₁H₈₀N₂O₁₃Si
• Molecular Weight: 1077.4
• Mol file: 885674-97-5.mol

Synonyms:

Chemical Property of C₆₁H₈₀N₂O₁₃Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₆₁H₈₀N₂O₁₃Si

There total 13 articles about C₆₁H₈₀N₂O₁₃Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-1-(4-methoxybenzyloxy)-2,2-dimethylhex-5-en-3-ol (885674-86-2) → C61H80N2O13Si (885674-97-5)

Guidance literature:

Multi-step reaction with 7 steps

1.1: 2,6-lutidine / CH₂Cl₂ / 4.5 h / 0 - 20 °C

2.1: O₃; PPh₃ / CH₂Cl₂ / -78 - 20 °C

3.1: NaHMDS; HMPA / tetrahydrofuran / -78 - 20 °C

4.1: Pd(PPh₃)4 / tetrahydrofuran / 2 h / 20 °C

5.1: TBAF*H₂O / tetrahydrofuran; H₂O; acetic acid / 48 h / 20 °C

6.1: Et₃N / PdCl₂(PPh₃)2; CuI / dimethylformamide / 5 h / 20 °C

7.1: 2,4,6-trichlorobenzoyl chloride; Et₃N / toluene / 0.75 h / 20 °C

7.2: DMAP / toluene / 5 h / 20 °C

With 2,6-dimethylpyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; 2,4,6-trichlorobenzoyl chloride; tetrabutyl ammonium fluoride; sodium hexamethyldisilazane; ozone; triethylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; toluene; 3.1: Stork-Zhao olefination / 4.1: Negishi coupling / 6.1: Sonogashira cross coupling reaction;

DOI:10.1002/ejoc.200500675

Reference yield:

(2'R)-2-(3'-hydroxy-2'-methoxy-propyl)-oxazole-4-carboxylic acid methyl ester (472979-70-7) → C61H80N2O13Si (885674-97-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: (ClCO)2; DMSO; Et₃N / CH₂Cl₂ / 3 h / -78 °C

1.2: 75 percent / K₂CO₃ / CH₂Cl₂; methanol / 18 h / 20 °C

2.1: Bu₃SnH / Pd(PPh₃)4 / tetrahydrofuran / 2 h / 20 °C

2.2: 88 percent / I₂ / tetrahydrofuran / -20 - 20 °C

3.1: Et₃N / PdCl₂(PPh₃)2; CuI / dimethylformamide / 5 h / 20 °C

4.1: 2,4,6-trichlorobenzoyl chloride; Et₃N / toluene / 0.75 h / 20 °C

4.2: DMAP / toluene / 5 h / 20 °C

With oxalyl dichloride; 2,4,6-trichlorobenzoyl chloride; tri-n-butyl-tin hydride; dimethyl sulfoxide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; 1.1: Swern oxidation / 3.1: Sonogashira cross coupling reaction;

DOI:10.1002/ejoc.200500675

Reference yield:

(S)-5-(4-Methoxy-benzyloxy)-4,4-dimethyl-3-triethylsilanyloxy-pentanal (885674-88-4) → C61H80N2O13Si (885674-97-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: NaHMDS; HMPA / tetrahydrofuran / -78 - 20 °C

2.1: Pd(PPh₃)4 / tetrahydrofuran / 2 h / 20 °C

3.1: TBAF*H₂O / tetrahydrofuran; H₂O; acetic acid / 48 h / 20 °C

4.1: Et₃N / PdCl₂(PPh₃)2; CuI / dimethylformamide / 5 h / 20 °C

5.1: 2,4,6-trichlorobenzoyl chloride; Et₃N / toluene / 0.75 h / 20 °C

5.2: DMAP / toluene / 5 h / 20 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; 2,4,6-trichlorobenzoyl chloride; tetrabutyl ammonium fluoride; sodium hexamethyldisilazane; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water; acetic acid; N,N-dimethyl-formamide; toluene; 1.1: Stork-Zhao olefination / 2.1: Negishi coupling / 4.1: Sonogashira cross coupling reaction;

DOI:10.1002/ejoc.200500675

upstream raw materials:

2-[(3E,7Z)-(2R,10S)-10-Hydroxy-2-methoxy-12-(4-methoxy-benzyloxy)-11,11-dimethyl-dodeca-3,7-dien-5-ynyl]-oxazole-4-carboxylic acid methyl ester

2-[(3E,7Z)-(2R,10S)-2-Methoxy-12-(4-methoxy-benzyloxy)-11,11-dimethyl-10-triethylsilanyloxy-dodeca-3,7-dien-5-ynyl]-oxazole-4-carboxylic acid

(Z)-(S)-1-(4-Methoxy-benzyloxy)-2,2-dimethyl-oct-5-en-7-yn-3-ol

(S)-5-(4-Methoxy-benzyloxy)-4,4-dimethyl-3-triethylsilanyloxy-pentanal

Downstream raw materials:

C₅₅H₆₆N₂O₁₃