Methyl demethoxycarbonylchafruticosinate

Base Information

• Chemical Name: Methyl demethoxycarbonylchafruticosinate
• CAS No.: 80151-89-9
• Molecular Formula: C21H24N2O3
• Molecular Weight: 352.42700
• Mol file: 80151-89-9.mol

Synonyms:

Chemical Property of Methyl demethoxycarbonylchafruticosinate

Chemical Property:

• PSA: 58.64000
• LogP: 2.18480

Purity/Quality:

98%min ^*data from raw suppliers

Methyldemethoxycarbonylchanofruticosinate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl demethoxycarbonylchafruticosinate

There total 31 articles about Methyl demethoxycarbonylchafruticosinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C30H38N2O2Si → (±)-methyl N-decarbomethoxy chanofruticosinate (80151-89-9)

Guidance literature:

Multi-step reaction with 12 steps

1.1: nickel(II) chloride hexahydrate; sodium tetrahydroborate; sodium hydroxide; hydrazine hydrate / ethanol / 5 h / 70 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; sodium carbonate; hydrogen / ethanol / 48 h / 760.05 Torr

3.1: sodium hydroxide / dichloromethane / 0.25 h / 0 °C

4.1: hydrogen bromide / tetrahydrofuran / 5 h / 0 °C

5.1: 4-methylmorpholine N-oxide; tetrapropylammonium perruthennate / dichloromethane / 0.5 h / 20 °C

6.1: samarium diiodide / tetrahydrofuran / 0.25 h / 20 °C

7.1: sodium; ammonia / tetrahydrofuran; tert-butyl alcohol / 0.5 h / -78 °C

8.1: borane-THF / tetrahydrofuran / 24 h / 0 - 70 °C / Inert atmosphere

8.2: 3 h / 0 - 20 °C

9.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

9.2: 0.33 h / -40 - 20 °C / Inert atmosphere

10.1: tetrahydrofuran; methanol / 50 °C

11.1: potassium carbonate; dihydrogen peroxide / methanol / 3 h / 20 °C

12.1: hydrogenchloride / 24 h / 60 °C

With hydrogenchloride; sodium tetrahydroborate; samarium diiodide; tetrapropylammonium perruthennate; borane-THF; nickel(II) chloride hexahydrate; palladium 10% on activated carbon; ammonia; hydrogen bromide; hydrogen; dihydrogen peroxide; sodium; sodium carbonate; potassium carbonate; hydrazine hydrate; 4-methylmorpholine N-oxide; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; ethanol; dichloromethane; tert-butyl alcohol;

DOI:10.1002/anie.201307788

Reference yield:

C30H40N2OSi → (±)-methyl N-decarbomethoxy chanofruticosinate (80151-89-9)

Guidance literature:

Multi-step reaction with 11 steps

1.1: palladium 10% on activated carbon; sodium carbonate; hydrogen / ethanol / 48 h / 760.05 Torr

2.1: sodium hydroxide / dichloromethane / 0.25 h / 0 °C

3.1: hydrogen bromide / tetrahydrofuran / 5 h / 0 °C

4.1: 4-methylmorpholine N-oxide; tetrapropylammonium perruthennate / dichloromethane / 0.5 h / 20 °C

5.1: samarium diiodide / tetrahydrofuran / 0.25 h / 20 °C

6.1: sodium; ammonia / tetrahydrofuran; tert-butyl alcohol / 0.5 h / -78 °C

7.1: borane-THF / tetrahydrofuran / 24 h / 0 - 70 °C / Inert atmosphere

7.2: 3 h / 0 - 20 °C

8.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

8.2: 0.33 h / -40 - 20 °C / Inert atmosphere

9.1: tetrahydrofuran; methanol / 50 °C

10.1: potassium carbonate; dihydrogen peroxide / methanol / 3 h / 20 °C

11.1: hydrogenchloride / 24 h / 60 °C

With hydrogenchloride; samarium diiodide; tetrapropylammonium perruthennate; borane-THF; palladium 10% on activated carbon; ammonia; hydrogen bromide; hydrogen; dihydrogen peroxide; sodium; sodium carbonate; potassium carbonate; 4-methylmorpholine N-oxide; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; ethanol; dichloromethane; tert-butyl alcohol;

DOI:10.1002/anie.201307788

Reference yield:

C30H42N2OSi → (±)-methyl N-decarbomethoxy chanofruticosinate (80151-89-9)

Guidance literature:

Multi-step reaction with 10 steps

1.1: sodium hydroxide / dichloromethane / 0.25 h / 0 °C

2.1: hydrogen bromide / tetrahydrofuran / 5 h / 0 °C

3.1: 4-methylmorpholine N-oxide; tetrapropylammonium perruthennate / dichloromethane / 0.5 h / 20 °C

4.1: samarium diiodide / tetrahydrofuran / 0.25 h / 20 °C

5.1: sodium; ammonia / tetrahydrofuran; tert-butyl alcohol / 0.5 h / -78 °C

6.1: borane-THF / tetrahydrofuran / 24 h / 0 - 70 °C / Inert atmosphere

6.2: 3 h / 0 - 20 °C

7.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

7.2: 0.33 h / -40 - 20 °C / Inert atmosphere

8.1: tetrahydrofuran; methanol / 50 °C

9.1: potassium carbonate; dihydrogen peroxide / methanol / 3 h / 20 °C

10.1: hydrogenchloride / 24 h / 60 °C

With hydrogenchloride; samarium diiodide; tetrapropylammonium perruthennate; borane-THF; ammonia; hydrogen bromide; dihydrogen peroxide; sodium; potassium carbonate; 4-methylmorpholine N-oxide; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; tert-butyl alcohol;

DOI:10.1002/anie.201307788

upstream raw materials:

methanol

(S)-tert-butyl 3-allyl-3-(2-cyanoethyl)-4-oxo-3,4-dihydro-1H-carbazole-9(2H)-carboxylate