1-Vinyl-4-methoxy-β-carboline

Base Information

• Chemical Name: 1-Vinyl-4-methoxy-β-carboline
• CAS No.: 26585-13-7
• Molecular Formula: C₁₄H₁₂N₂O
• Molecular Weight: 224.262
• Hs Code.: 2933990090
• Mol file: 26585-13-7.mol

Synonyms:9H-Pyrido[3,4-b]indole,4-methoxy-1-vinyl- (8CI);4-Methoxy-1-vinyl-b-carboline;Dehydrocrenatine;1-Ethenyl-4-methoxy-9H-b-carboline;1-Vinyl-4-methoxy-b-carboline;

Chemical Property of 1-Vinyl-4-methoxy-β-carboline

Chemical Property:

• Vapor Pressure: 3E-08mmHg at 25°C
• Refractive Index: 1.737
• Boiling Point: 461.2 °C at 760 mmHg
• Flash Point: 151.1 °C
• PSA: 37.91000
• Density: 1.251 g/cm³
• LogP: 3.36770

Purity/Quality:

98%min ^*data from raw suppliers

Dehydrocrenatine ≥98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Vinyl-4-methoxy-β-carboline

There total 9 articles about 1-Vinyl-4-methoxy-β-carboline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

methyl-triphenylphosphonium iodide (2065-66-9) + 4-methoxy-β-carboline-1-carbaldehyde (92631-69-1) → 1-vinyl-4-dimethoxy-β-carboline (26585-13-7)

Guidance literature:

methyl-triphenylphosphonium iodide; With n-butyllithium; In tetrahydrofuran; hexane; at 20 ℃; for 2h;

4-methoxy-β-carboline-1-carbaldehyde; In tetrahydrofuran; hexane; at 70 ℃; for 2h;

DOI:10.1248/cpb.53.653

Reference yield: 51.0%

Methylenetriphenylphosphorane (19493-09-5) + 4-methoxy-β-carboline-1-carbaldehyde (92631-69-1) → 1-vinyl-4-dimethoxy-β-carboline (26585-13-7)

Guidance literature:

In tetrahydrofuran;

DOI:10.1016/j.bmcl.2004.01.055

Reference yield: 19.0%

1-(1-hydroxyethyl)-4-methoxy-β-carboline (864156-32-1) → 1-vinyl-4-dimethoxy-β-carboline (26585-13-7)

Guidance literature:

With methanesulfonyl chloride; triethylamine; In dichloromethane; at 20 ℃; for 8h;

DOI:10.1248/cpb.53.653

upstream raw materials:

Methylenetriphenylphosphorane

4-methoxy-β-carboline-1-carbaldehyde

1-(1-hydroxyethyl)-4-methoxy-β-carboline

methyl-triphenylphosphonium iodide

Downstream raw materials:

crenatine

Refernces

• 1、 Takasu, Kiyosei,Shimogama, Tsubasa,Saiin, Chalerm,Kim, Hye-Sook,Wataya, Yusuke,Ihara, Masataka. "π-Delocalized β-carbolinium cations as potential antimalarials". . p. 1689 - 1692. Retrieved 2007/10/03.