benzyl-(2-fluoro-1,1-bis-fluoromethyl-ethyl)-amine

Base Information

Chemical Name:benzyl-(2-fluoro-1,1-bis-fluoromethyl-ethyl)-amine
CAS No.:228547-77-1
Molecular Formula:C₁₁H₁₄F₃N
Molecular Weight:217.234
Hs Code.:

Synonyms:

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Chemical Property of benzyl-(2-fluoro-1,1-bis-fluoromethyl-ethyl)-amine

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Technology Process of benzyl-(2-fluoro-1,1-bis-fluoromethyl-ethyl)-amine

There total 5 articles about benzyl-(2-fluoro-1,1-bis-fluoromethyl-ethyl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-52-7
benzaldehyde

: 228547-77-1
benzyl-(2-fluoro-1,1-bis-fluoromethyl-ethyl)-amine

Guidance literature:: Multi-step reaction with 5 steps

1: TsOH / benzene / 3 h / Heating

2: NaBH₃CN / tetrahydrofuran

3: 81 percent / thionyl chloride, i-Pr₂NEt / CH₂Cl₂ / 1 h / -20 °C

4: sodium periodate, ruthenium(III) chloride hydrate / acetonitrile; H₂O / 1 h / 0 °C

5: 1.) tetrabutylammonium fluoride; 2.) 20 percent H₂SO₄ / 1.) THF, 5 h, r.t.; 2.) ether, 18 h, r.t.

With ruthenium trichloride; sodium periodate; thionyl chloride; sulfuric acid; tetrabutyl ammonium fluoride; sodium cyanoborohydride; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water; acetonitrile; benzene;
DOI:10.1016/S0040-4039(99)00633-4

Reference yield:

: 3-Fluoro-2-fluoromethyl-2-{[1-phenyl-meth-(E)-ylidene]-amino}-propan-1-ol

: 228547-77-1
benzyl-(2-fluoro-1,1-bis-fluoromethyl-ethyl)-amine

Guidance literature:: Multi-step reaction with 4 steps

1: NaBH₃CN / tetrahydrofuran

2: 81 percent / thionyl chloride, i-Pr₂NEt / CH₂Cl₂ / 1 h / -20 °C

3: sodium periodate, ruthenium(III) chloride hydrate / acetonitrile; H₂O / 1 h / 0 °C

4: 1.) tetrabutylammonium fluoride; 2.) 20 percent H₂SO₄ / 1.) THF, 5 h, r.t.; 2.) ether, 18 h, r.t.

With ruthenium trichloride; sodium periodate; thionyl chloride; sulfuric acid; tetrabutyl ammonium fluoride; sodium cyanoborohydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1016/S0040-4039(99)00633-4

Reference yield:

: 228547-74-8
2-benzylamino-3-fluoro-2-fluoromethyl-propan-1-ol

: 228547-77-1
benzyl-(2-fluoro-1,1-bis-fluoromethyl-ethyl)-amine

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / thionyl chloride, i-Pr₂NEt / CH₂Cl₂ / 1 h / -20 °C

2: sodium periodate, ruthenium(III) chloride hydrate / acetonitrile; H₂O / 1 h / 0 °C

3: 1.) tetrabutylammonium fluoride; 2.) 20 percent H₂SO₄ / 1.) THF, 5 h, r.t.; 2.) ether, 18 h, r.t.

With ruthenium trichloride; sodium periodate; thionyl chloride; sulfuric acid; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; In dichloromethane; water; acetonitrile;
DOI:10.1016/S0040-4039(99)00633-4