(E)-tert-butyl 1-((3-(4-cyano-2,6-dimethylheptan-4-yl)-4-methoxyphenyl)sulfonyl)-6-(3-ethoxy-3-oxoprop-1-en-1-yl)spiro[indoline-3,4'-piperidine]-1'-carboxylate

Base Information

Chemical Name:(E)-tert-butyl 1-((3-(4-cyano-2,6-dimethylheptan-4-yl)-4-methoxyphenyl)sulfonyl)-6-(3-ethoxy-3-oxoprop-1-en-1-yl)spiro[indoline-3,4'-piperidine]-1'-carboxylate
CAS No.:1620580-60-0
Molecular Formula:C₃₉H₅₃N₃O₇S
Molecular Weight:707.932
Hs Code.:

(E)-tert-butyl 1-((3-(4-cyano-2,6-dimethylheptan-4-yl)-4-methoxyphenyl)sulfonyl)-6-(3-ethoxy-3-oxoprop-1-en-1-yl)spiro[indoline-3,4'-piperidine]-1'-carboxylate

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Chemical Property of (E)-tert-butyl 1-((3-(4-cyano-2,6-dimethylheptan-4-yl)-4-methoxyphenyl)sulfonyl)-6-(3-ethoxy-3-oxoprop-1-en-1-yl)spiro[indoline-3,4'-piperidine]-1'-carboxylate

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Technology Process of (E)-tert-butyl 1-((3-(4-cyano-2,6-dimethylheptan-4-yl)-4-methoxyphenyl)sulfonyl)-6-(3-ethoxy-3-oxoprop-1-en-1-yl)spiro[indoline-3,4'-piperidine]-1'-carboxylate

There total 4 articles about (E)-tert-butyl 1-((3-(4-cyano-2,6-dimethylheptan-4-yl)-4-methoxyphenyl)sulfonyl)-6-(3-ethoxy-3-oxoprop-1-en-1-yl)spiro[indoline-3,4'-piperidine]-1'-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1620581-44-3
tert-butyl 1-((3-(4-cyano-2,6-dimethylheptan-4-yl)-4-methoxyphenyl)sulfonyl)spiro[indoline-3,4'-piperidine]-1'-carboxylate

: 140-88-5,9003-32-1
ethyl acrylate

: 1620580-60-0
(E)-tert-butyl 1-((3-(4-cyano-2,6-dimethylheptan-4-yl)-4-methoxyphenyl)sulfonyl)-6-(3-ethoxy-3-oxoprop-1-en-1-yl)spiro[indoline-3,4'-piperidine]-1'-carboxylate

Guidance literature:: With silver(I) acetate; palladium diacetate; N-acetylglycine; at 55 ℃; for 24h; regioselective reaction; Sealed tube;
DOI:10.1021/ja505737x

Reference yield:

: 1620581-27-2
C₁₇H₂₄ClNO₃S

: 1620580-60-0
(E)-tert-butyl 1-((3-(4-cyano-2,6-dimethylheptan-4-yl)-4-methoxyphenyl)sulfonyl)-6-(3-ethoxy-3-oxoprop-1-en-1-yl)spiro[indoline-3,4'-piperidine]-1'-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0 - 23 °C

2: palladium diacetate; N-acetylglycine; silver(I) acetate / 24 h / 55 °C / Sealed tube

With silver(I) acetate; palladium diacetate; triethylamine; N-acetylglycine; In dichloromethane;
DOI:10.1021/ja505737x

Reference yield:

: 7035-03-2
2-methoxy-benzeneacetonitrile

: 1620580-60-0
(E)-tert-butyl 1-((3-(4-cyano-2,6-dimethylheptan-4-yl)-4-methoxyphenyl)sulfonyl)-6-(3-ethoxy-3-oxoprop-1-en-1-yl)spiro[indoline-3,4'-piperidine]-1'-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 23 °C

2: chlorosulfonic acid / chloroform / 1.5 h / 0 - 23 °C

3: triethylamine / dichloromethane / 0 - 23 °C

4: palladium diacetate; N-acetylglycine; silver(I) acetate / 24 h / 55 °C / Sealed tube

With chlorosulfonic acid; silver(I) acetate; palladium diacetate; sodium hydride; triethylamine; N-acetylglycine; In dichloromethane; chloroform; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/ja505737x