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Delafloxacin

Base Information Edit
  • Chemical Name:Delafloxacin
  • CAS No.:189279-58-1
  • Deprecated CAS:579508-20-6
  • Molecular Formula:C18H12ClF3N4O4
  • Molecular Weight:440.766
  • Hs Code.:
  • UNII:6315412YVF
  • DSSTox Substance ID:DTXSID40172331
  • Nikkaji Number:J1.257.530K
  • Wikipedia:Delafloxacin
  • Wikidata:Q5253067
  • NCI Thesaurus Code:C87390
  • RXCUI:1927663
  • Metabolomics Workbench ID:153018
  • ChEMBL ID:CHEMBL2105637
  • Mol file:189279-58-1.mol
Delafloxacin

Synonyms:1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-7-(3-hydroxyazetidin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid;3-quinolinecarboxylic acid, 1-(6-amino-3,5-difluoro-2-pyridinyl)-8-chloro-6-fluoro-1,4-dihydro-7-(3-hydroxy-1-azetidinyl)-4-oxo-;ABT 492;ABT-492;ABT492;Baxdela;delafloxacin;RX-3341

Suppliers and Price of Delafloxacin
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • Delafloxacin
  • 25mg
  • $ 305.00
  • DC Chemicals
  • Delafloxacin(ABT-492) >98%
  • 1 g
  • $ 1500.00
  • Crysdot
  • Delafloxacin 98+%
  • 50mg
  • $ 965.00
  • Crysdot
  • Delafloxacin 98+%
  • 25mg
  • $ 568.00
  • Crysdot
  • Delafloxacin 98+%
  • 10mg
  • $ 318.00
  • Chemenu
  • Delafloxacin 98%
  • 100mg
  • $ 468.00
  • Cayman Chemical
  • Delafloxacin 98%
  • 25mg
  • $ 438.00
  • Cayman Chemical
  • Delafloxacin 98%
  • 1mg
  • $ 25.00
  • Cayman Chemical
  • Delafloxacin 98%
  • 10mg
  • $ 200.00
  • Cayman Chemical
  • Delafloxacin 98%
  • 5mg
  • $ 113.00
Total 1 raw suppliers
Chemical Property of Delafloxacin Edit
Chemical Property:
  • Melting Point:238-241℃ 
  • Boiling Point:698.5 °C at 760 mmHg 
  • PKA:5.49±0.50(Predicted) 
  • Flash Point:376.2 °C 
  • PSA:121.68000 
  • Density:1.796 g/cm3 
  • LogP:2.56390 
  • Storage Temp.:2-8°C 
  • Solubility.:DMSO (Slightly), Methanol (Very Slightly, Heated, Sonicated) 
  • XLogP3:2.7
  • Hydrogen Bond Donor Count:3
  • Hydrogen Bond Acceptor Count:11
  • Rotatable Bond Count:3
  • Exact Mass:440.0499171
  • Heavy Atom Count:30
  • Complexity:755
Purity/Quality:

99% *data from raw suppliers

Delafloxacin *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:

SDS file from LookChem

Useful:
  • Drug Classes:Antiinfective Agents
  • Canonical SMILES:C1C(CN1C2=C(C=C3C(=C2Cl)N(C=C(C3=O)C(=O)O)C4=C(C=C(C(=N4)N)F)F)F)O
  • Recent ClinicalTrials:Delafloxacin IV and OS Administration Compared to Best Available Therapy in Patients With Surgical Site Infections
  • Recent EU Clinical Trials:A randomized, observer-blinded, active-controlled, Phase IIIb study to compare IV / Oral delafloxacin fixed-dose monotherapy with best available treatments in a microbiologically enriched population with surgical site infections
  • Uses Delafloxacin is a potent agent and broad-spectrum anionic fluoroquinolone against Streptococcus pneumoniae and diverse group of pathogens.
Technology Process of Delafloxacin

There total 28 articles about Delafloxacin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
With sodium hydroxide; In ethanol; water; at 20 - 30 ℃; for 3h;
Guidance literature:
With N-chloro-succinimide; sulfuric acid; In ethyl acetate; at 20 ℃; Cooling with ice; Large scale;
Refernces Edit
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