6-Chloro-2-fluoro-3-methoxyphenylboronicacid

Base Information

• Chemical Name: 6-Chloro-2-fluoro-3-methoxyphenylboronicacid
• CAS No.: 867333-04-8
• Molecular Formula: C7H7BClFO3
• Molecular Weight: 204.393
• Hs Code.: 2931900090
• Mol file: 867333-04-8.mol

Synonyms:(6-chloro-2-fluoro-3-methoxyphenyl)boronic acid;

Chemical Property of 6-Chloro-2-fluoro-3-methoxyphenylboronicacid

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 355.694oC at 760 mmHg
• PKA: 7.60±0.58(Predicted)
• Flash Point: 168.918oC
• PSA: 49.69000
• Density: 1.405g/cm3
• LogP: 0.16750

Purity/Quality:

99% ^*data from raw suppliers

6-Chloro-2-fluoro-3-methoxyphenylboronicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: suzuki reaction 6-Chloro-2-fluoro-3-methoxyphenylboronic acid

Technology Process of 6-Chloro-2-fluoro-3-methoxyphenylboronicacid

There total 2 articles about 6-Chloro-2-fluoro-3-methoxyphenylboronicacid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

Trimethyl borate (121-43-7,63156-11-6) + 4-chloro-2-fluoro-1-methoxybenzene (452-09-5) → (6-chloro-2-fluoro-3-methoxyphenyl) boronic acid (867333-04-8)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; cyclohexane; at -60 ℃; Flow reactor;

DOI:10.1021/op500213j

Reference yield: 39.0%

4-chloro-2-fluoro-1-methoxybenzene (452-09-5) → (6-chloro-2-fluoro-3-methoxyphenyl) boronic acid (867333-04-8)

Guidance literature:

4-chloro-2-fluoro-1-methoxybenzene; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.333333h;

With Trimethyl borate; In tetrahydrofuran; at -78 - 20 ℃; for 2h;

With hydrogenchloride; water; In tetrahydrofuran;

Reference yield:

(6-chloro-2-fluoro-3-methoxyphenyl) boronic acid (867333-04-8) → 4-[4-chloro-3-(4-chlorophenyl)-2-fluoro-phenoxy]piperidine trifluoroacetate

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / water; 1,4-dioxane / 1 h / 110 °C / Inert atmosphere; Microwave irradiation

2: boron tribromide / dichloromethane / 12 h / -78 - 20 °C / Inert atmosphere

3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

4: dichloromethane / 5 h / 20 °C / Inert atmosphere

With di-isopropyl azodicarboxylate; boron tribromide; potassium carbonate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;

upstream raw materials:

4-chloro-2-fluoro-1-methoxybenzene

Trimethyl borate

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