2-ethyl-N-[3-(2-pyridinyl)-1-isoquinolinyl]hexanamide

Base Information

• Chemical Name: 2-ethyl-N-[3-(2-pyridinyl)-1-isoquinolinyl]hexanamide
• CAS No.: 112575-46-9
• Molecular Formula: C₂₂H₂₅N₃O
• Molecular Weight: 347.46
• Mol file: 112575-46-9.mol

Synonyms:

Chemical Property of 2-ethyl-N-[3-(2-pyridinyl)-1-isoquinolinyl]hexanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-ethyl-N-[3-(2-pyridinyl)-1-isoquinolinyl]hexanamide

There total 3 articles about 2-ethyl-N-[3-(2-pyridinyl)-1-isoquinolinyl]hexanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

1-amino-3-(2-pyridinyl)isoquinoline (37989-04-1) + 2-ethylhexanoic acid chloride (760-67-8) → N-<3-(2-pyridyl)isoquinolin-1-yl>-2-ethylhexanamide (112575-46-9)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at -10 ℃; for 1h;

DOI:10.1021/jm00399a005

Reference yield:

2-Cyanopyridine (100-70-9,1232006-36-8) → N-<3-(2-pyridyl)isoquinolin-1-yl>-2-ethylhexanamide (112575-46-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / potassium amide / liquid ammonia; diethyl ether; tetrahydrofuran / 1.) -78 deg C, 20 min, 2.) reflux, 2 h

2: 59 percent / n-butyllithium / tetrahydrofuran; hexane / 1 h / -10 °C

With n-butyllithium; potassium amide; In tetrahydrofuran; diethyl ether; hexane; ammonia;

DOI:10.1021/jm00399a005

Reference yield:

2-Methylbenzonitrile (529-19-1) → N-<3-(2-pyridyl)isoquinolin-1-yl>-2-ethylhexanamide (112575-46-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / potassium amide / liquid ammonia; diethyl ether; tetrahydrofuran / 1.) -78 deg C, 20 min, 2.) reflux, 2 h

2: 59 percent / n-butyllithium / tetrahydrofuran; hexane / 1 h / -10 °C

With n-butyllithium; potassium amide; In tetrahydrofuran; diethyl ether; hexane; ammonia;

DOI:10.1021/jm00399a005

upstream raw materials:

1-amino-3-(2-pyridinyl)isoquinoline

2-ethylhexanoic acid chloride

2-Cyanopyridine

2-Methylbenzonitrile

Refernces