ETHYL 4-CHLORONICOTINATE HCL

Base Information

• Chemical Name: ETHYL 4-CHLORONICOTINATE HCL
• CAS No.: 174496-99-2
• Molecular Formula: C8H9Cl2NO2
• Molecular Weight: 222.071
• Hs Code.: 2933399090
• Mol file: 174496-99-2.mol

Synonyms:ETHYL 4-CHLORONICOTINATE HCL;4-Chloronicotinic acid ethyl ester hydrochloride;ethy 4-chloronicotinate hydrochloride;Ethyl 4-chloronicotinate hydrochloride;ethyl 4-chloropyridine-3-carboxylate hydrochloride;

Chemical Property of ETHYL 4-CHLORONICOTINATE HCL

Chemical Property:

• PSA: 39.19000
• LogP: 2.71370
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Ethyl4-ChloronicotinateHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 4-CHLORONICOTINATE HCL

There total 1 articles about ETHYL 4-CHLORONICOTINATE HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 4-chloronicotinate (37831-62-2) → ethyl 4-chloropyridine-3-carboxylate hydrochloride (174496-99-2)

Guidance literature:

ethyl 4-chloronicotinate; With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; for 5h; Cooling with ice; Inert atmosphere; Reflux;

With hydrogenchloride; In ethyl acetate; at 20 ℃;

Reference yield: 92.0%

ethyl 4-chloropyridine-3-carboxylate hydrochloride (174496-99-2) + 4-fluoroboronic acid (1765-93-1) → 4-(4-fluorophenyl)nicotinic acid ethyl ester

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,2-dimethoxyethane; water; at 85 ℃; Inert atmosphere;

DOI:10.1002/cmdc.201300144

Reference yield: 91.0%

ethyl 4-chloropyridine-3-carboxylate hydrochloride (174496-99-2) + 2-Chlorobenzeneboronic acid (3900-89-8) → 4-(2-chlorophenyl)nicotinic acid ethyl ester

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,2-dimethoxyethane; water; at 85 ℃; Inert atmosphere;

DOI:10.1002/cmdc.201300144

upstream raw materials:

ethyl 4-chloronicotinate

Downstream raw materials:

Ethyl 4-phenylpyridine-3-carboxylate

4-(2-methylphenyl)nicotinic acid ethyl ester

4-(2,6-difluorophenyl)nicotinic acid ethyl ester

ethyl 4-(p-tolyl)nicotinate

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