5-(3-Hydroxypropyl)-2-methoxyphenol

Base Information

Chemical Name:5-(3-Hydroxypropyl)-2-methoxyphenol
CAS No.:57627-75-5
Molecular Formula:C10H14O3
Molecular Weight:182.21600
Hs Code.:2909500000
DSSTox Substance ID:DTXSID90553873
Wikidata:Q72484755
Mol file:57627-75-5.mol

Synonyms:5-(3-Hydroxypropyl)-2-methoxyphenol;57627-75-5;3-Hydroxy-4-methoxybenzenepropanol;SCHEMBL15535668;DTXSID90553873;AKOS005217799;CS-0302353;2-[(THIEN-2-YLMETHYL)THIO]BENZOICACID;EN300-1850324

Suppliers and Price of 5-(3-Hydroxypropyl)-2-methoxyphenol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3-Hydroxy-4-methoxybenzenepropanol
1g
$ 360.00

Medical Isotopes, Inc.
3-Hydroxy-4-methoxybenzenepropanol
250 mg
$ 625.00

Crysdot
5-(3-Hydroxypropyl)-2-methoxyphenol 95+%
1g
$ 535.00

Chemenu
5-(3-Hydroxypropyl)-2-methoxyphenol 95%
1g
$ 505.00

American Custom Chemicals Corporation
5-(3-HYDROXYPROPYL)-2-METHOXYPHENOL 95.00%
5MG
$ 501.59

Total 14 raw suppliers

Chemical Property of 5-(3-Hydroxypropyl)-2-methoxyphenol

Chemical Property:

Melting Point:63-67°C
Boiling Point:342.0±27.0 °C(Predicted)
PKA:10.00±0.10(Predicted)
PSA：49.69000
Density:1.148±0.06 g/cm3(Predicted)
LogP:1.32570
Storage Temp.:2-8°C
Solubility.:DMSO (Slightly), Methanol (Slightly)
XLogP3:0.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:182.094294304
Heavy Atom Count:13
Complexity:138

Purity/Quality:

98%Min ^*data from raw suppliers

3-Hydroxy-4-methoxybenzenepropanol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C(C=C1)CCCO)O
Uses 3-Hydroxy-4-methoxybenzenepropanol is an intermediate in the synthesis of Advantame (A307000), a high-intensity, low calorie sweetner.

Technology Process of 5-(3-Hydroxypropyl)-2-methoxyphenol

There total 5 articles about 5-(3-Hydroxypropyl)-2-methoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-(3-acetoxy-4-methoxyphenyl)acrylic acid ethyl ester

: 57627-75-5
5-(3-hydroxy-propyl)-2-methoxy-phenol

Guidance literature:: 3-(3-acetoxy-4-methoxyphenyl)acrylic acid ethyl ester; With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃;

With lithium aluminium tetrahydride; In tetrahydrofuran; Heating;
DOI:10.1021/jf011103j

Reference yield:

: 881-57-2
isovanillin acetate

: 57627-75-5
5-(3-hydroxy-propyl)-2-methoxy-phenol

Guidance literature:: Multi-step reaction with 2 steps

1.1: CH₂Cl₂ / Heating

2.1: H₂ / 10 percent Pd/C / ethyl acetate / 20 °C

2.2: LiAlH₄ / tetrahydrofuran / Heating

With hydrogen; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1021/jf011103j

Reference yield:

: 84428-16-0
ethyl 3-(3'-hydroxy-4'-methoxyphenyl)propanoate

: 57627-75-5
5-(3-hydroxy-propyl)-2-methoxy-phenol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 3h; Inert atmosphere;
DOI:10.1002/chem.202100762