881-57-2

Basic information

• Product Name: CHEMBRDG-BB 9071542
• Synonyms: CHEMBRDG-BB 9071542;5-FORMYL-2-METHOXYPHENYL ACETATE;5-formyl-2-methoxyphenyl acetate(SALTDATA: FREE);O-Acetyl Isovanillin;3-Acetoxy-4-Methoxybenzaldehyde;3-(Acetyloxy)-4-Methoxy-benzaldehyde;3-Hydroxy-p-anisaldehyde Acetate;(5-methanoyl-2-methoxy-phenyl) ethanoate
• CAS NO: 881-57-2
• Molecular Formula: C₁₀H₁₀O₄
• Molecular Weight: 194.19
• Product Categories: Aromatics;Intermediates
• Mol File: 881-57-2.mol
• Article Data: 15

Chemical Properties

• Melting Point: 85.0 to 89.0 °C
• Boiling Point: 293°C at 760 mmHg
• Flash Point: 127.4°C
• Appearance: /
• Density: 1.193g/cm³
• Vapor Pressure: 0.00177mmHg at 25°C
• Refractive Index: 1.539
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: Dichloromethane
• CAS DataBase Reference: CHEMBRDG-BB 9071542(CAS DataBase Reference)
• NIST Chemistry Reference: CHEMBRDG-BB 9071542(881-57-2)
• EPA Substance Registry System: CHEMBRDG-BB 9071542(881-57-2)

Safety Data

• Hazardous Substances Data: 881-57-2(Hazardous Substances Data)

Usage

Chemical Properties

Light Yellow Solid

InChI:InChI=1/C10H10O4/c1-7(12)14-10-5-8(6-11)3-4-9(10)13-2/h3-6H,1-2H3

Upstream product

• 621-59-0 isovanillin 
• 108-24-7 acetic anhydride 
• 2973-59-3 2-bromoisovanillin 
• 69048-79-9 4-bromo-5-formyl-2-methoxyphenyl acetate 
• 75-36-5 acetyl chloride 
• 1225192-73-3 C₁₀H₁₃NO₃ 
• 71155-68-5 3-Acetoxy-4-methoxy-1-(diacetoxymethyl)benzene 
• 113042-92-5 (E)-3,3'-diacetoxy-4'-methoxy-5-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyloxy)stilbene 
• 186581-53-3 diazomethane 
• 65298-99-9 acetic acid 5-formyl-2-hydroxy-phenyl ester 
• 123-08-0 4-hydroxy-benzaldehyde 

Downstream Products

• 134841-10-4 (2E)-3-[(3-acetyloxy)-4-methoxyphenyl]acrylic acid 
• 81109-23-1 (3S,4R)-3-(3-Acetoxy-4-methoxy-phenyl)-8-hydroxy-1-oxo-isochroman-4-carboxylic acid 
• 60444-56-6 3-acetoxy-4-methoxybenzoic acid 
• 100976-73-6 5t-(3-acetoxy-4-methoxy-phenyl)-penta-2t,4-dienoic acid methyl ester 
• 63867-05-0 3-acetoxy-4-methoxybenzyl alcohol 
• 80547-69-9 3-hydroxy-4-methoxy-5-nitrobenzaldehyde 

Relevant articles and documents

Electrochemical detection of atrazine in wastewater samples by copper oxide (CuO) nanoparticles ionic liquid modified electrode

In the present report, a new voltammetric sensor based on copper oxide nanoparticles involved in 2-(3-acetoxy-4-methoxybenzylidenamino)-thiophenol (AMT) ionic liquid (CuO NPs/ILs) was developed for atrazine (ATR) analysis. Firstly, the CuO NPs/ILs modifie

Synthesis and Biochemical Evaluation of 3-Phenoxy-1,4-diarylazetidin-2-ones as Tubulin-Targeting Antitumor Agents

Structure-activity relationships for a series of 3-phenoxy-1,4-diarylazetidin-2-ones were investigated, leading to the discovery of a number of potent antiproliferative compounds, including trans-4-(3-hydroxy-4-methoxyphenyl)-3-phenoxy-1-(3,4,5-trimethoxyphenyl)azetidin-2-one (78b) and trans-4-(3-amino-4-methoxyphenyl)-3-phenoxy-1-(3,4,5-trimethoxyphenyl)azetidin-2-one (90b). X-ray crystallography studies indicate the potential importance of the torsional angle between the 1-phenyl A ring and 4-phenyl B ring for potent antiproliferative activity and that a trans configuration between the 3-phenoxy and 4-phenyl rings is generally optimal. These compounds displayed IC50 values of 38 and 19 nM, respectively, in MCF-7 breast cancer cells, inhibited the polymerization of isolated tubulin in vitro, disrupted the microtubular structure in MCF-7 cells as visualized by confocal microscopy, and caused G2/M arrest and apoptosis. Compound 90b possessed a mean GI50 value of 22 nM in the NCI60 cell line screen, displayed minimal cytotoxicity, and was shown to interact at the colchicine-binding site on β-tubulin. Phosphate and amino acid prodrugs of both 78b and 90b were synthesized, of which the alanine amide 102b retained potency and is a promising candidate for further clinical development.

Exploring the formation and recognition of an important G-quadruplex in a HIF1α promoter and its transcriptional inhibition by a benzo[c]phenanthridine derivative

Four putative G-quadruplex sequences (PGSs) in the HIF1α promoter and the 5′UTR were evaluated for their G-quadruplex-forming potential using ESI-MS, CD, FRET, DMS footprinting, and a polymerase stop assay. An important G-quadruplex (S1) has been proven to inhibit HIF1α transcription by blocking AP2 binding. A benzo[c]phenanthridine derivative was found to target the S1 G-quadruplex and induce its conformational conversion from antiparallel to parallel orientation. The transcriptional suppression of HIF1α by this compound was demonstrated using western blotting, Q-RT-PCR, luciferase assay, and ChIP. Our new findings provided a novel strategy for HIF1α regulation and potential insight for cancer therapy.