(S)-2-(diphenylacetyl)-1,2,3,4-tetrahydro-6-methoxy-5-(phenylmethoxy)-3-isoquinoline carboxylic acid, tromethamine salt

Base Information

• Chemical Name: (S)-2-(diphenylacetyl)-1,2,3,4-tetrahydro-6-methoxy-5-(phenylmethoxy)-3-isoquinoline carboxylic acid, tromethamine salt
• CAS No.: 1356460-50-8
• Molecular Formula: C₄H₁₁NO₃*C₃₂H₂₉NO₅
• Molecular Weight: 628.722
• Mol file: 1356460-50-8.mol

Synonyms:

Chemical Property of (S)-2-(diphenylacetyl)-1,2,3,4-tetrahydro-6-methoxy-5-(phenylmethoxy)-3-isoquinoline carboxylic acid, tromethamine salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-(diphenylacetyl)-1,2,3,4-tetrahydro-6-methoxy-5-(phenylmethoxy)-3-isoquinoline carboxylic acid, tromethamine salt

There total 3 articles about (S)-2-(diphenylacetyl)-1,2,3,4-tetrahydro-6-methoxy-5-(phenylmethoxy)-3-isoquinoline carboxylic acid, tromethamine salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-(diphenylacetyl)-1,2,3,4-tetrahydro-6-methoxy-5-(phenylmethoxy)-3-isoquinolinecarboxylic acid sodium salt (1316755-17-5) → (S)-2-(diphenylacetyl)-1,2,3,4-tetrahydro-6-methoxy-5-(phenylmethoxy)-3-isoquinoline carboxylic acid, tromethamine salt (1356460-50-8)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / ethyl acetate; water

2: isopropyl alcohol / 5.5 h / 5 - 50 °C

With hydrogenchloride; In water; ethyl acetate; isopropyl alcohol;

Reference yield:

2,2-diphenyl-1-(1H-pyrazol-1-yl)ethan-1-one (551909-81-0) → (S)-2-(diphenylacetyl)-1,2,3,4-tetrahydro-6-methoxy-5-(phenylmethoxy)-3-isoquinoline carboxylic acid, tromethamine salt (1356460-50-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: N,N,N',N'-tetramethylguanidine / N,N-dimethyl-formamide / 1 h / Inert atmosphere

1.2: 16 h

2.1: hydrogenchloride / ethyl acetate; water

3.1: isopropyl alcohol / 5.5 h / 5 - 50 °C

With hydrogenchloride; N,N,N',N'-tetramethylguanidine; In water; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

(3S)-5-(benzyloxy)-6-methoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (1356460-51-9) → (S)-2-(diphenylacetyl)-1,2,3,4-tetrahydro-6-methoxy-5-(phenylmethoxy)-3-isoquinoline carboxylic acid, tromethamine salt (1356460-50-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: chloro-trimethyl-silane; pyridine / dichloromethane / 0.33 h / -12 - -10 °C / Inert atmosphere

1.2: 0.25 h / -12 - -10 °C

2.1: hydrogenchloride / ethyl acetate; water

3.1: isopropyl alcohol / 5.5 h / 5 - 50 °C

With pyridine; hydrogenchloride; chloro-trimethyl-silane; In dichloromethane; water; ethyl acetate; isopropyl alcohol;

upstream raw materials:

(S)-2-(diphenylacetyl)-1,2,3,4-tetrahydro-6-methoxy-5-(phenylmethoxy)-3-isoquinolinecarboxylic acid sodium salt

(3S)-5-(benzyloxy)-6-methoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

2,2-diphenyl-1-(1H-pyrazol-1-yl)ethan-1-one