Thieno[3,2-d]pyrimidin-4-amine

Base Information

• Chemical Name: Thieno[3,2-d]pyrimidin-4-amine
• CAS No.: 16285-74-8
• Molecular Formula: C6H5N3S
• Molecular Weight: 151.18900
• Hs Code.: 2934999090
• European Community (EC) Number: 865-423-2
• ChEMBL ID: CHEMBL2113965
• DSSTox Substance ID: DTXSID60467695
• Wikidata: Q82294745
• Mol file: 16285-74-8.mol

Synonyms:thieno[3,2-d]pyrimidin-4-amine;16285-74-8;4-Aminothieno[3,2-d]pyrimidine;OSM-S-71;MFCD09834952;thieno[3,2-d]pyrimidin-4-ylamine;SCHEMBL1160677;CHEMBL2113965;DTXSID60467695;QIZMFTNGJPBSBT-UHFFFAOYSA-N;AKOS015902877;AB52930;4-Aminothieno[3 pound not2-d]pyrimidine;AS-31607;SY007976;4-(4-Bromo-pyrazol-1-ylmethyl)-benzoicacid;CS-0054403;FT-0704263;EN300-64094;A882776;Z390143644

Chemical Property of Thieno[3,2-d]pyrimidin-4-amine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 226 °C
• Boiling Point: 346.799oC at 760 mmHg
• PKA: 5.39±0.30(Predicted)
• Flash Point: 163.538oC
• PSA: 80.04000
• Density: 1.486g/cm3
• LogP: 1.85470
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility.: Acetonitrile (Slightly), DMSO (Slightly)
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 151.02041835
• Heavy Atom Count: 10
• Complexity: 130

Purity/Quality:

97% ^*data from raw suppliers

4-Aminothieno[3,2-d]pyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CSC2=C1N=CN=C2N
• Uses: 4-Aminothieno[3,2-d]pyrimidine is a useful research intermediate

Technology Process of Thieno[3,2-d]pyrimidin-4-amine

There total 2 articles about Thieno[3,2-d]pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.4%

4-chlorothieno[3,2-d]pyrimidine (16269-66-2) → thieno[3,2-d]pyrimidin-4-amine (16285-74-8)

Guidance literature:

With ammonium hydroxide; In ethanol; at 60 ℃; for 8h;

DOI:10.2174/1573406412666151215105149

Reference yield:

→ thieno[3,2-d]pyrimidin-4-amine (16285-74-8)

Guidance literature:

4-Chlor-thieno<3,2-d>pyrimidin, Me./NH4OH;

Reference yield:

2,6-dichlorophenylisocyanate (39920-37-1) + thieno[3,2-d]pyrimidin-4-amine (16285-74-8) → 1-(2,6-dichlorophenyl)-3-(thieno[3,2-d]pyrimidin-4-yl)urea

Guidance literature:

In acetonitrile; at 17 - 25 ℃; for 16h;

upstream raw materials:

4-chlorothieno[3,2-d]pyrimidine