4-Bromo-8-trifluoromethylquinoline

Base Information

• Chemical Name: 4-Bromo-8-trifluoromethylquinoline
• CAS No.: 260973-10-2
• Molecular Formula: C10H5BrF3N
• Molecular Weight: 276.056
• Hs Code.: 2933499090
• Mol file: 260973-10-2.mol

Synonyms:Quinoline, 4-bromo-8-(trifluoromethyl)-;

Chemical Property of 4-Bromo-8-trifluoromethylquinoline

Chemical Property:

• Vapor Pressure: 0.00189mmHg at 25°C
• Refractive Index: 1.573
• Boiling Point: 301.3 °C at 760 mmHg
• PKA: 1.12±0.30(Predicted)
• Flash Point: 136 °C
• Density: 1.658 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

4-Bromo-8-trifluoromethylquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25-36
• Safety Statements: 26-45

MSDS Files:

Useful:

Technology Process of 4-Bromo-8-trifluoromethylquinoline

There total 1 articles about 4-Bromo-8-trifluoromethylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

4-hydroxy-8-trifluoromethylquinoline (23779-96-6) → 4-bromo-8-(trifluoromethyl)quinoline (260973-10-2)

Guidance literature:

With phosphorus tribromide; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield: 61.0%

4-bromo-8-(trifluoromethyl)quinoline (260973-10-2) + N-(4-fluorophenyl)-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide → N‐(4‐fluorophenyl)‐2‐{4‐[8‐(trifluoromethyl)quinolin‐4‐yl]phenyl}acetamide

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; cesium fluoride; In 1,4-dioxane; at 100 ℃; for 6h;

Reference yield:

4-bromo-8-(trifluoromethyl)quinoline (260973-10-2) + 3-Formylphenylboronic acid (87199-16-4) → 3-(8-(trifluoromethyl)quinolin-4-yl)benzaldehyde (1037432-23-7)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; for 1h; Product distribution / selectivity; Heating / reflux;

upstream raw materials:

4-hydroxy-8-trifluoromethylquinoline

Downstream raw materials:

3-(8-(trifluoromethyl)quinolin-4-yl)benzaldehyde

Refernces