23779-96-6

Basic information

• Product Name: 8-(TRIFLUOROMETHYL)QUINOLIN-4-OL
• Synonyms: BUTTPARK 13\01-63;4-HYDROXY-8-(TRIFLUOROMETHYL)QUINOLINE;8-(TRIFLUOROMETHYL)QUINOLIN-4-OL;8-(TRIFLUOROMETHYL)-4-QUINOLINOL;4-hydroxy-8-(trfluoroMethyl)quinoline
• CAS NO: 23779-96-6
• Molecular Formula: C₁₀H₆F₃NO
• Molecular Weight: 213.16
• EINECS: 245-879-3
• Product Categories: Heterocycles;Quinoline&Isoquinoline;Quinolines, Isoquinolines & Quinoxalines
• Mol File: 23779-96-6.mol
• Article Data: 5

Chemical Properties

• Melting Point: 174-176 °C(lit.)
• Boiling Point: 269.649 °C at 760 mmHg
• Flash Point: 116.88 °C
• Appearance: /
• Density: 1.37 g/cm³
• Vapor Pressure: 0.00716mmHg at 25°C
• Refractive Index: 1.509
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.51±0.40(Predicted)
• CAS DataBase Reference: 8-(TRIFLUOROMETHYL)QUINOLIN-4-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 8-(TRIFLUOROMETHYL)QUINOLIN-4-OL(23779-96-6)
• EPA Substance Registry System: 8-(TRIFLUOROMETHYL)QUINOLIN-4-OL(23779-96-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 23779-96-6(Hazardous Substances Data)

Usage

General Description

8-(Trifluoromethyl)quinolin-4-ol is a chemical compound that belongs to the quinolinol family. It has a molecular formula of C10H6F3NO with a molecular weight of 209.16 g/mol. 8-(TRIFLUOROMETHYL)QUINOLIN-4-OL is a derivative of quinoline and contains a trifluoromethyl group, which contributes to its unique chemical properties. It is used in the pharmaceutical industry as an intermediate for the synthesis of various pharmaceutical drugs and has potential biological and medicinal applications. The presence of a hydroxyl group in the structure of 8-(Trifluoromethyl)quinolin-4-ol also makes it a potentially important building block for the development of new drugs and materials.

InChI:InChI=1/C10H6F3NO/c11-10(12,13)7-3-1-2-6-8(15)4-5-14-9(6)7/h1-5H,(H,14,15)

Upstream product

• 31601-88-4 3-carboxy-8-trifluoromethyl-4-quinolone 
• 31601-87-3 3-carbethoxy-8-trifluoromethyl-4-quinolone 
• 450383-19-4 2,2-dimethyl-5-({[2-(trifluoromethyl)phenyl]amino}methylidene)-1,3-dioxane-4,6-dione 
• 314055-37-3 N-(2-(trifluoromethyl)phenyl)pyrazine-2-carboxamide 
• 72787-99-6 N-phenyl-isoquinoline-1-carboxamide 
• 1575754-64-1 N-phenylisoquinoline-3-carboxamide 
• 24691-94-9 N-phenyl-3-methyl-2-pyridinecarboxamide 
• 34067-83-9 N-(phenyl)pyrazine-2-carboxamide 
• 88-17-5 2-(trifluoromethyl)benzenamine 
• 10354-53-7 N-phenylpicolinamide 

Downstream Products

• 23779-97-7 4-chloro-8-(trifluoromethyl)quinoline 
• 23779-99-9 floctafenine 
• 260973-10-2 4-bromo-8-(trifluoromethyl)quinoline 
• 57369-92-3 4-hydrazineyl-8-(trifluoromethyl)quinoline 
• 1033810-06-8 4-(2-chloro-4-nitrophenoxy)-8-(trifluoromethyl)quinoline 
• 854778-27-1 3-phenyl-8-(trifluoromethyl)quinolin-4-ol 
• 854775-30-7 methyl {4-[({3-[3-phenyl-8-(trifluoromethyl)quinolin-4-yl]phenyl}amino)methyl]phenyl}acetate 
• 854769-68-9 {3-[3-phenyl-8-(trifluoromethyl)quinolin-4-yl]phenyl}amine 
• 854778-28-2 4-bromo-3-phenyl-8-(trifluoromethyl)quinoline 
• 854778-26-0 3-bromo-8-(trifluoromethyl)quinolin-4-ol 

Relevant articles and documents

Unsymmetrical bisquinolines with high potency against P. falciparum Malaria

Quinoline-based scaffolds have been the mainstay of antimalarial drugs, including many artemisinin combination therapies (ACTs), over the history ofmoderndrugdevelopment. Althoughmuch progress has beenmade in the search for novel antimalarial scaffolds, itmay be that quinolineswill remain useful, especially if very potent compounds fromthis class are discovered. We report here the results of a structure-activity relationship(SAR) study assessingpotentialunsymmetrical bisquinoline antiplasmodial drug candidates using in vitro activity against intact parasites in cell culture. Many unsymmetrical bisquinolineswere found to be highly potent against both chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum parasites. Further work to develop such compounds could focus on minimizing toxicities in order to find suitable candidates for clinical evaluation.

Synthesis of novel halogenated 4(1H)-quinolones by thermolysis of arylaminomethylene-1,3-dioxane-4,6-diones

A variety of novel 4(1H)-quinolone derivatives were prepared by thermolysis of aminomethylene Meldrum's acid derivatives. Georg Thieme Verlag Stuttgart.

Preparation of 4-hydroxyquinolines

Process for the preparation of 4-hydroxyquinolines of the general formula: STR1 in which R represents a hydrogen atom, or one, two or three substituents, which may be the same or different, selected from halogen atoms, alkyl radicals containing 1 to 4 carbon atoms, alkoxy radicals containing 1 to 4 carbon atoms, and the trifluoromethyl radical, the substituent(s) being in the 2-, 3-, 5-, 6-, 7- or 8-position, by the oxidation, by means of oxygen or air, in the presence of a catalyst based on platinum or ruthenium, or alloys thereof, of a 1,2,3,4-tetrahydroquinolin-4-one of the general formula: STR2 in which R is as defined above.