(R)-N-Fmoc-2-(7'-octenyl) alanine

Base Information

• Chemical Name: (R)-N-Fmoc-2-(7'-octenyl) alanine
• CAS No.: 945212-26-0
• Molecular Formula: C26H31NO4
• Molecular Weight: 421.536
• Hs Code.: 2924299090
• Mol file: 945212-26-0.mol

Synonyms:(2R)-2-{[;(R)-2-{[(;(R)-2-{[(;(R)-N-Fmoc-α-(7-octenyl)alanine;945212-26-0;9-Decenoi;L B656 HHJ H1OVMX1&VQ7U1 &&R Form

Chemical Property of (R)-N-Fmoc-2-(7'-octenyl) alanine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.567
• Boiling Point: 588.348°C at 760 mmHg
• PKA: 3.94±0.41(Predicted)
• Flash Point: 309.622°C
• PSA: 75.63000
• Density: 1.141g/cm³
• LogP: 6.28590
• Storage Temp.: ?20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

(2R)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-2-methyl-9-decenoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): N
• Hazard Codes: N
• Statements: 50
• Safety Statements: 61

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (2R)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-2-methyl-9-decenoic Acid, is a stable antimicrobial peptide, that can be isolated from the venom of wild bee Lasioglossum laticeps.

Technology Process of (R)-N-Fmoc-2-(7'-octenyl) alanine

There total 2 articles about (R)-N-Fmoc-2-(7'-octenyl) alanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-2-amino-2-methyl-dec-9-enoic acid hydrochloride (1609117-03-4) + N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) → Fmoc-(R)-2-(7-octenyl)alanine (945212-26-0,288617-75-4)

Guidance literature:

With sodium carbonate; In tetrahydrofuran; water; at 20 - 25 ℃; pH=8.5 - 9; Large scale;

Reference yield:

C26H31NO4*C6H13N (1609117-04-5) → Fmoc-(R)-2-(7-octenyl)alanine (945212-26-0,288617-75-4)

Guidance literature:

With sulfuric acid; In tert-butyl methyl ether; water; pH=2 - 2.5; Large scale;

Reference yield:

fluorescein-5-isothiocyanate (18861-78-4) + (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)hept-6-enoic acid (856412-22-1) + Fmoc-Val-OH (68858-20-8) + Fmoc-Leu-OH (35661-60-0) + N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine (35661-39-3,136132-75-7) + Fmoc-(R)-2-(7-octenyl)alanine (945212-26-0,288617-75-4) + N-Fmoc-Tyr-OH (112883-29-1,92954-90-0) + N-α-9-fluorenylmethoxycarbonyl-aspartic acid (136083-57-3,136083-73-3,119062-05-4) + Fmoc-Ile-OH (71989-23-6,251316-98-0) + Fmoc-Lys-OH (105047-45-8) + N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-glutamine (71989-20-3) + Fmoc-L-Arg-OH (91000-69-0,130752-32-8) + 8-(9-fluorenylmethyloxycarbonyl-amino)-3,6-dioxaoctanoic acid (166108-71-0,675606-79-8) → fluorescein isothiocyanate-[8-amino-3,6-dioxaoctanoyl]-VNAKQY-((R)-2-(7-octenyl)alanine)- R I L K R R-((S)-2-(4-pentenyl)glycine)-ARAKL

Guidance literature:

Fmoc-Leu-OH; With 1-[(1-(cyano-?2-?ethoxy-?2-?oxoethylidenaminooxy)?dimethylamino-?morpholino)]-uronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; ethyl cyanoglyoxylate-2-oxime; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h;

With piperidine; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h;

fluorescein-5-isothiocyanate; (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)hept-6-enoic acid; Fmoc-Val-OH; N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine; Fmoc-(R)-2-(7-octenyl)alanine; N-Fmoc-Tyr-OH; N-α-9-fluorenylmethoxycarbonyl-aspartic acid; Fmoc-Ile-OH; Fmoc-Lys-OH; N₂-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-glutamine; Fmoc-L-Arg-OH; 8-(9-fluorenylmethyloxycarbonyl-amino)-3,6-dioxaoctanoic acid; Further stages;

DOI:10.1002/anie.201907901

upstream raw materials:

C₂₆H₃₁NO₄*C₆H₁₃N

(R)-2-amino-2-methyl-dec-9-enoic acid hydrochloride

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

Downstream raw materials:

C₂₆H₃₁NO₄*C₆H₁₃N

Refernces