4-(2-(4-tolylsulfanyl)phenyl)piperidin monomaleate

Base Information

Chemical Name:4-(2-(4-tolylsulfanyl)phenyl)piperidin monomaleate
CAS No.:1093111-60-4
Molecular Formula:C₄H₄O₄*C₁₈H₂₁NS
Molecular Weight:399.511
Hs Code.:

Synonyms:

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Chemical Property of 4-(2-(4-tolylsulfanyl)phenyl)piperidin monomaleate

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Technology Process of 4-(2-(4-tolylsulfanyl)phenyl)piperidin monomaleate

There total 7 articles about 4-(2-(4-tolylsulfanyl)phenyl)piperidin monomaleate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 508233-95-2
4-[2-(4-methylphenylsulfanyl)phenyl]piperidine

: 110-16-7,26099-09-2
maleic acid

: 1093111-60-4
4-(2-(4-tolylsulfanyl)phenyl)piperidin monomaleate

Guidance literature:

Reference yield:

: 106-45-6
para-thiocresol

: 1093111-60-4
4-(2-(4-tolylsulfanyl)phenyl)piperidin monomaleate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 2 - 3 h / 70 - 120 °C

2.1: n-butyllithium / hexane; n-heptane / 1.17 h / 20 °C

2.2: -40 °C

2.3: 0 - 10 °C

3.1: triethylsilane; trifluoroacetic acid / 18 h / 50 - 60 °C

4.1: hydrogen bromide; acetic acid / 18 h / 45 - 80 °C

5.1: sodium hydroxide; water / ethyl acetate / 0.25 h / pH 13 - 14

With triethylsilane; sodium hydroxide; n-butyllithium; potassium tert-butylate; water; hydrogen bromide; acetic acid; trifluoroacetic acid; In 1-methyl-pyrrolidin-2-one; hexane; n-heptane; ethyl acetate;

Reference yield:

: 960151-85-3
ethyl 4-(2-(4-tolylsulfanyl)phenyl)piperidin-1-carboxylate

: 1093111-60-4
4-(2-(4-tolylsulfanyl)phenyl)piperidin monomaleate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen bromide; acetic acid / 18 h / 45 - 80 °C

2: sodium hydroxide; water / ethyl acetate / 0.25 h / pH 13 - 14

With sodium hydroxide; water; hydrogen bromide; acetic acid; In ethyl acetate;